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Table 3 Two sets of mean absolute variability (AV) values and intraclass correlation coefficients (ICC) of the binding potential (BPND) of [11C]SCH23390 in four brain regions derived from two different methods (each defined in the leftmost column) in each of three parts of the image analysis process: (1) manual/FreeSurfer ROIs, (2) no realignment/realignment, and (3) manual cerebellum ROI/automated FSL cerebellum ROI)

From: [11C]SCH23390 binding to the D1-dopamine receptor in the human brain—a comparison of manual and automated methods for image analysis

Method (1/2) ROI AV (%) method 1 AV (%) method 2 AV diff (95% CI) ICC (95% CI) Method 1 ICC (95% CI) Method 2
ROI definition
Method 1: manual
Method 2: FreeSurfer
CAU 9.45 9.79 1.61 (− 1.96, 1.27) 0.79 (0.49, 0.92) 0.87 (0.66, 0.95)
PUT 4.82 4.72 0.95 (− 0.86, 1.05) 0.73 (0.38, 0.90) 0.84 (0.59, 0.94)
DLPFC 13.17 14.30 2.67 (− 3.79, 1.55) 0.72 (0.36, 0.89) 0.72 (0.36, 0.90)
INS 9.73 7.94 1.76 (0.03, 3.54) 0.31 (− 0.25, 0.70) 0.46 (− 0.07, 0.78)
Movement correction
Method 1: none
Method 2: realignment
CAU 13.78 6.81 4.43 (2.55, 11.40) 0.79 (0.50, 0.93) 0.86 (0.64, 0.95)
PUT 5.88 3.76 1.68 (0.45, 3.80) 0.75 (0.40, 0.91) 0.81 (0.53, 0.93)
DLPFC 19.48 10.08 6.08 (3.32, 15.48) 0.63 (0.21, 0.86) 0.77 (0.44, 0.91)
INS 9.40 8.47 1.50 (− 0.56, 2.44) 0.38 (− 0.18, 0.74) 0.37 (− 0.18, 0.74)
Definition of reference region (cerebellum)
Method 1: manual
Method 2: FSL
CAU 10.60 9.15 1.86 (− 0.41, 3.30) 0.81 (0.53, 0.93) 0.84 (0.59, 0.94)
PUT 5.37 4.38 2.04 (1.05, 3.03) 0.77 (0.45, 0.91) 0.76 (0.41, 0.91)
DLPFC 15.29 11.54 6.08 (− 2.33, 9.82) 0.71 (0.33, 0.89) 0.73 (0.38, 0.90)
INS 10.73 7.88 2.81 (0.05, 5.66) 0.23 (−0.34, 0.66) 0.50 (− 0.02, 0.80)