Table 3 Two sets of mean absolute variability (AV) values and intraclass correlation coefficients (ICC) of the binding potential (BPND) of [11C]SCH23390 in four brain regions derived from two different methods (each defined in the leftmost column) in each of three parts of the image analysis process: (1) manual/FreeSurfer ROIs, (2) no realignment/realignment, and (3) manual cerebellum ROI/automated FSL cerebellum ROI)
Method (1/2) | ROI | AV (%) method 1 | AV (%) method 2 | AV diff (95% CI) | ICC (95% CI) Method 1 | ICC (95% CI) Method 2 |
|---|---|---|---|---|---|---|
ROI definition Method 1: manual Method 2: FreeSurfer | CAU | 9.45 | 9.79 | 1.61 (− 1.96, 1.27) | 0.79 (0.49, 0.92) | 0.87 (0.66, 0.95) |
PUT | 4.82 | 4.72 | 0.95 (− 0.86, 1.05) | 0.73 (0.38, 0.90) | 0.84 (0.59, 0.94) | |
DLPFC | 13.17 | 14.30 | 2.67 (− 3.79, 1.55) | 0.72 (0.36, 0.89) | 0.72 (0.36, 0.90) | |
INS | 9.73 | 7.94 | 1.76 (0.03, 3.54) | 0.31 (− 0.25, 0.70) | 0.46 (− 0.07, 0.78) | |
Movement correction Method 1: none Method 2: realignment | CAU | 13.78 | 6.81 | 4.43 (2.55, 11.40) | 0.79 (0.50, 0.93) | 0.86 (0.64, 0.95) |
PUT | 5.88 | 3.76 | 1.68 (0.45, 3.80) | 0.75 (0.40, 0.91) | 0.81 (0.53, 0.93) | |
DLPFC | 19.48 | 10.08 | 6.08 (3.32, 15.48) | 0.63 (0.21, 0.86) | 0.77 (0.44, 0.91) | |
INS | 9.40 | 8.47 | 1.50 (− 0.56, 2.44) | 0.38 (− 0.18, 0.74) | 0.37 (− 0.18, 0.74) | |
Definition of reference region (cerebellum) Method 1: manual Method 2: FSL | CAU | 10.60 | 9.15 | 1.86 (− 0.41, 3.30) | 0.81 (0.53, 0.93) | 0.84 (0.59, 0.94) |
PUT | 5.37 | 4.38 | 2.04 (1.05, 3.03) | 0.77 (0.45, 0.91) | 0.76 (0.41, 0.91) | |
DLPFC | 15.29 | 11.54 | 6.08 (− 2.33, 9.82) | 0.71 (0.33, 0.89) | 0.73 (0.38, 0.90) | |
INS | 10.73 | 7.88 | 2.81 (0.05, 5.66) | 0.23 (−0.34, 0.66) | 0.50 (− 0.02, 0.80) |