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Table 2 ROI volumes and binding potential (BPND) values for [11C]SCH23390 binding obtained by two repeated PET measurements analyzed by three different comparisons of methods: (1) ROI definition (manual (Man)/FreeSurfer (FS)), (2) movement correction (no realignment/realignment), and (3) definition of the cerebellum as reference region (manual/modified FSL)

From: [11C]SCH23390 binding to the D1-dopamine receptor in the human brain—a comparison of manual and automated methods for image analysis

  CAU PUT DLPFC INS CBL
ROI volume by ROI method (mL) Man FS Man FS Man FS Man FS Man FSL
 Median 6.5 9.5 8.4 13.0 39.3 53.7 10.8 16.6 7.6 8.1
 Interquartile range 5.7–8.8 8.8–9.9 8.0–9.4 12.4–13.8 37.4–43.4 49.2–57.2 10.0–11.1 16.4–18.2 6.3–8.3 6.9–10.1
 CoV % 16.4 8.9 12.9 8.4 15.8 10.0 9.1 8.0 19.2 21.1
 Mean diff (CI 95%) − 3.1 (− 3.4, − 2.8)a − 4.5 (− 5.0, −3.9)a − 12 (− 15.9, − 9.8)a − 6.7 (− 7.4, − 6.0)a − 1.0 (− 2.0, − 0.4)a
BPND by ROI method Man FS Man FS Man FS Man FS   
 Median 1.65 1.39 1.85 1.62 0.32 0.26 0.55 0.53   
 Interquartile range 1.43–1.76 1.14–1.52 1.72–1.88 1.49–1.68 0.26–0.33 0.21–0.29 0.50–0.58 0.50–0.57   
 CoV % 16.1 20.9 7.0 8.9 17.0 19.4 8.8 8.4   
 Mean diff (CI 95%) 0.28 (0.24, 0.31)a 0.20 (0.17, 0.23)a 0.05 (0.04, 0.06) 0.01 (0.01, 0.02)   
BPND by realignment No realign Realign No realign Realign No realign Realign No realign Realign   
 Median 1.46 1.57 1.74 1.73 0.27 0.30 0.54 0.53   
 Interquartile range 1.24–1.63 1.33–1.65 1.61–1.81 1.61–1.75 0.21–0.29 0.26–0.32 0.50–0.58 0.50–0.58   
 CoV % 22.1 14.7 9.0 9.7 21.2 15.4 8.8 8.2   
 Mean diff (CI 95%) − 0.10 (− 0.16, − 0.05)a 0.00 (− 0.03, 0.03) − 0.04 (− 0.05, − 0.02)a 0.00 (− 0.01, 0.01)   
BPND by reference region Man CBL FSL CBL Man CBL FSL CBL Man CBL FSL CBL Man CBL FSL CBL   
 Median 1.49 1.53 1.70 1.77 0.28 0.29 0.52 0.55   
 Interquartile range 1.26–1.62 1.31–1.67 1.58–1.76 1.63–1.80 0.22–0.30 0.25–0.31 0.49–0.57 0.51–0.58   
 CoV % 18.7 17.6 8.3 7.3 18.8 16.9 8.8 8.3   
 Mean diff (CI 95%) − 0.04 (− 0.06, − 0.03)a − 0.05 (− 0.06, − 0.03)a − 0.02 (− 0.03, − 0.01)a − 0.03 (− 0.03, − 0.01)a   
  1. The values were obtained from four brain regions in 15 subjects, each value represents the mean of the eight values for that measurement or part of the analysis. Interquartile range = 25th to 75th percent
  2. CoV coefficient of variation, CI confidence interval
  3. aThe confidence interval does not contain zero