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Table 2 ROI volumes and binding potential (BPND) values for [11C]SCH23390 binding obtained by two repeated PET measurements analyzed by three different comparisons of methods: (1) ROI definition (manual (Man)/FreeSurfer (FS)), (2) movement correction (no realignment/realignment), and (3) definition of the cerebellum as reference region (manual/modified FSL)

From: [11C]SCH23390 binding to the D1-dopamine receptor in the human brain—a comparison of manual and automated methods for image analysis

 

CAU

PUT

DLPFC

INS

CBL

ROI volume by ROI method (mL)

Man

FS

Man

FS

Man

FS

Man

FS

Man

FSL

 Median

6.5

9.5

8.4

13.0

39.3

53.7

10.8

16.6

7.6

8.1

 Interquartile range

5.7–8.8

8.8–9.9

8.0–9.4

12.4–13.8

37.4–43.4

49.2–57.2

10.0–11.1

16.4–18.2

6.3–8.3

6.9–10.1

 CoV %

16.4

8.9

12.9

8.4

15.8

10.0

9.1

8.0

19.2

21.1

 Mean diff (CI 95%)

− 3.1 (− 3.4, − 2.8)a

− 4.5 (− 5.0, −3.9)a

− 12 (− 15.9, − 9.8)a

− 6.7 (− 7.4, − 6.0)a

− 1.0 (− 2.0, − 0.4)a

BPND by ROI method

Man

FS

Man

FS

Man

FS

Man

FS

  

 Median

1.65

1.39

1.85

1.62

0.32

0.26

0.55

0.53

  

 Interquartile range

1.43–1.76

1.14–1.52

1.72–1.88

1.49–1.68

0.26–0.33

0.21–0.29

0.50–0.58

0.50–0.57

  

 CoV %

16.1

20.9

7.0

8.9

17.0

19.4

8.8

8.4

  

 Mean diff (CI 95%)

0.28 (0.24, 0.31)a

0.20 (0.17, 0.23)a

0.05 (0.04, 0.06)

0.01 (0.01, 0.02)

  

BPND by realignment

No realign

Realign

No realign

Realign

No realign

Realign

No realign

Realign

  

 Median

1.46

1.57

1.74

1.73

0.27

0.30

0.54

0.53

  

 Interquartile range

1.24–1.63

1.33–1.65

1.61–1.81

1.61–1.75

0.21–0.29

0.26–0.32

0.50–0.58

0.50–0.58

  

 CoV %

22.1

14.7

9.0

9.7

21.2

15.4

8.8

8.2

  

 Mean diff (CI 95%)

− 0.10 (− 0.16, − 0.05)a

0.00 (− 0.03, 0.03)

− 0.04 (− 0.05, − 0.02)a

0.00 (− 0.01, 0.01)

  

BPND by reference region

Man CBL

FSL CBL

Man CBL

FSL CBL

Man CBL

FSL CBL

Man CBL

FSL CBL

  

 Median

1.49

1.53

1.70

1.77

0.28

0.29

0.52

0.55

  

 Interquartile range

1.26–1.62

1.31–1.67

1.58–1.76

1.63–1.80

0.22–0.30

0.25–0.31

0.49–0.57

0.51–0.58

  

 CoV %

18.7

17.6

8.3

7.3

18.8

16.9

8.8

8.3

  

 Mean diff (CI 95%)

− 0.04 (− 0.06, − 0.03)a

− 0.05 (− 0.06, − 0.03)a

− 0.02 (− 0.03, − 0.01)a

− 0.03 (− 0.03, − 0.01)a

  
  1. The values were obtained from four brain regions in 15 subjects, each value represents the mean of the eight values for that measurement or part of the analysis. Interquartile range = 25th to 75th percent
  2. CoV coefficient of variation, CI confidence interval
  3. aThe confidence interval does not contain zero