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Table 1 The percentage increase/decrease for different parameters comparing 8 TOF BSREM reconstructions with reference TOF OSEM reconstructions

From: Quantitative performance and optimal regularization parameter in block sequential regularized expectation maximization reconstructions in clinical 68Ga-PSMA PET/MR

 

TOF BSREM

β = 300

β = 350

β = 400

β = 450

β = 500

β = 550

β = 600

β = 700

Background SUVmean

0.0% (0.60)

0.0% (0.63)

0.0% (0.65)

0.1% (0.69)

0.1% (0.67)

0.1% (0.69)

0.1% (0.75)

0.1% (0.87)

Background SUVstd

22.0% (< 0.01)

H

8.3% (< 0.01)

H

−1.0% (0.41)

− 9.2% (< 0.01)

L

− 15.2% (< 0.01)

L

−18.4% (< 0.01)

L

− 21.0% (< 0.01)

L

−27.0% (< 0.01)

L

Small size, low-uptake lesions (N = 8)

SUVmax

28.0% (0.02)

H

17.7% (0.15)

8.0% (0.55)

−1.6% (0.74)

− 8.1% (0.25)

−12.8% (0.11)

− 18.1% (0.05)

L

− 24.6% (0.02)

L

CR

32.4% (0.02)

H

20.2% (0.15)

8.1% (0.55)

− 2.8% (0.74)

−10.0% (0.15)

−15.4% (0.08)

− 21.6% (0.05)

L

− 29.3% (0.02)

L

Medium size, medium uptake lesions (N = 15)

SUVmax

27.0% (< 0.01)

H

18.6% (< 0.01)

H

14.5% (0.01)

H

10.5% (0.08)

− 0.4% (0.64)

− 3.3% (0.42)

− 5.8% (0.21)

− 10.6% (< 0.01)

L

CR

28.2% (< 0.01)

H

20.4% (< 0.01)

H

15.6% (0.02)

H

8.8% (0.15)

0.1% (0.89)

− 2.9% (0.42)

− 5.5% (0.06)

−12.4% (< 0.01)

L

Large size, high-uptake lesions (N = 17)

SUVmax

16.3% (< 0.01)

H

11.5% (< 0.01)

H

7.0% (< 0.01)

H

4.1% (0.01)

H

1.8% (0.19)

0.3% (0.43)

− 1.7% (0.89)

− 4.9% (0.03)

L

CR

17.4% (< 0.01)

H

12.5% (< 0.01)

H

9.1% (< 0.01)

H

6.2% (< 0.01)

H

2.9% (0.08)

0.2% (0.46)

− 1.9% (0.71)

− 5.2% (0.02)

L

  1. The regularization parameter applied in TOF BSREM is indicated by the β value (top). P values are listed in parentheses. H indicates significantly higher values, and L indicates significantly lower parameter values for TOF BSREM compared to reference TOF OSEM with 28 subsets and 2 iterations SUV standardized uptake value, SUVmax the average of the hottest 5 voxels in the lesion, CR the percentage increase of the tumor to background ratio of the indicated reconstruction compared to the reference TOF OSEM reconstruction with 2 iterations and 28 subsets, TOF time-of-flight, OSEM ordered subset expectation maximization, BSREM block sequential regularized expectation maximization