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EJNMMI Research
Fig. 1 | EJNMMI Research

Fig. 1

From: Non-invasive kinetic modelling of PET tracers with radiometabolites using a constrained simultaneous estimation method: evaluation with 11C-SB201745

Fig. 1

Constrained SIME model used in the analysis. CP represents the AIF, CF represents the free state and CB of the 2-TC model. The CP was modelled as a product of plasma to whole blood ratio and the Hill function. Three parameters of the Hill function (a, b, c) and two parameters of the straight line function (d, e) were optimised simultaneously by fitting N (where N=4) TACs extracted from different brain regions. CWB is derived from PV-corrected PET images. TACs derived from the cerebellum, parietal cortex, hippocampus and striatum from one subject are shown on the right

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