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Table 2 Summary of comparisons between independent readers, reader A and reader B, and automated thresholding segmentations using the Z-score (Z-A and Z-B) and SUV > 1 (SUV). Values for dice similarity coefficient (DSC), true positive volume fraction (TPVF) and 1 minus false positive volume fraction (1-FPVF) are shown

From: A semi-automatic technique to quantify complex tuberculous lung lesions on 18F-fluorodeoxyglucose positron emission tomography/computerised tomography images

  Dx and M6 Dx M6
Median Range Median Range Median Range
DSC
 Z-A to reader A 0.75 0.57–0.91 0.85 0.57–0.91 0.68 0.61–0.84
 Z-A to reader B 0.66 0.31–0.94 0.77 0.56–0.94 0.55 0.31–0.79
 Z-A to intersection 0.73 0.46–0.89 0.81 0.49–0.89 0.64 0.46–0.78
 Z-A to union 0.72 0.30–0.94 0.81 0.63–0.94 0.55 0.30–0.85
 SUV to reader A 0.68 0.21–0.90 0.74 0.57–0.90 0.47 0.21–0.77
 SUV to reader B 0.63 0.19–0.91 0.75 0.57–0.91 0.45 0.19–0.71
 SUV to intersection 0.61 0.11–0.88 0.74 0.50–0.88 0.45 0.11–0.69
 SUV to union 0.7 0.18–0.92 0.77 0.64–0.92 0.37 0.18–0.79
 Z-A to SUV 0.88 0.15–0.99 0.88 0.75–0.97 0.59 0.15–0.99
 Z-B to Z-A 0.83 0.59–0.99 0.89 0.79–0.99 0.63 0.59–0.95
 Reader B to A 0.78 0.42–0.92 0.83 0.78–0.92 0.64 0.42–0.85
TPVF (%)
 Z-A to reader A 91.4 55.48–100.00 98.9 89.21–100.00 78.5 55.48–93.65
 Z-A to reader B 80.5 18.22–99.91 96.3 70.18–99.91 62.0 18.22–94.05
 Z-A to intersection 98.0 59.56–100.00 99.9 94.35–100.00 87.5 59.56–98.56
 Z-A to union 77.8 17.86–99.92 96.0 70.82–99.92 77.8 17.86–90.34
 SUV to reader A 99.4 34.64–100.00 99.8 99.34–100.00 96.6 34.64–100.00
 SUV to reader B 92.0 31.92–99.63 96.7 72.27–99.63 84.8 31.92–96.95
 SUV to intersection 100.0 53.19–100.00 100.0 99.83–100.00 99.8 53.19–100.00
 SUV to union 95.4 24.64–99.91 96.4 73.04–99.91 95.3 24.64–97.28
 Z-A to SUV 91.4 17.09–100.00 87.9 59.49–100.00 97.5 17.09–100.00
 Z-B to Z-A 92.7 56.35–100.00 86.9 70.80–100.00 100.0 56.35–100.00
 Reader B to A 81.4 50.25–98.10 88.5 79.06–98.10 71.1 50.25–93.15
1-FPVF(%)
 Z-A to reader A 68.8 40.61–88.04 74.5 40.61–84.70 61.3 55.79–88.04
 Z-A to reader B 68.3 31.79–100.00 74.4 39.29–91.24 52.9 31.79–100.00
 Z-A to intersection 62.7 30.95–88.04 70.8 32.51–79.93 47.9 30.95–88.04
 Z-A to union 75.7 30.54–100.00 88.3 46.25–92.29 62.2 30.54–100.00
 SUV to reader A 57.7 11.82–81.57 59.2 39.99–81.57 54.4 11.82–73.02
 SUV to reader B 54.6 10.97–85.55 74.6 40.51–85.55 42.8 10.97–70.14
 SUV to intersection 48.6 6.10–78.25 58.2 32.94–78.25 30.2 6.10–69.07
 SUV to union 66.0 9.91–88.88 75.7 46.85–88.88 55.2 9.91–74.10
 Z-A to SUV 100.0 8.36–100.00 100.0 77.01–100.00 100.0 8.36–100.00
 Z-B to Z-A 87.3 44.02–100.00 90.3 86.36–100.00 61.5 44.02–89.62
 Reader B to A 77.3 26.93–95.40 77.7 65.93–95.40 59.1 26.93–95.32