Table 2 Summary of comparisons between independent readers, reader A and reader B, and automated thresholding segmentations using the Z-score (Z-A and Z-B) and SUV > 1 (SUV). Values for dice similarity coefficient (DSC), true positive volume fraction (TPVF) and 1 minus false positive volume fraction (1-FPVF) are shown
| Â | Dx and M6 | Dx | M6 | |||
|---|---|---|---|---|---|---|
Median | Range | Median | Range | Median | Range | |
DSC | ||||||
 Z-A to reader A | 0.75 | 0.57–0.91 | 0.85 | 0.57–0.91 | 0.68 | 0.61–0.84 |
 Z-A to reader B | 0.66 | 0.31–0.94 | 0.77 | 0.56–0.94 | 0.55 | 0.31–0.79 |
 Z-A to intersection | 0.73 | 0.46–0.89 | 0.81 | 0.49–0.89 | 0.64 | 0.46–0.78 |
 Z-A to union | 0.72 | 0.30–0.94 | 0.81 | 0.63–0.94 | 0.55 | 0.30–0.85 |
 SUV to reader A | 0.68 | 0.21–0.90 | 0.74 | 0.57–0.90 | 0.47 | 0.21–0.77 |
 SUV to reader B | 0.63 | 0.19–0.91 | 0.75 | 0.57–0.91 | 0.45 | 0.19–0.71 |
 SUV to intersection | 0.61 | 0.11–0.88 | 0.74 | 0.50–0.88 | 0.45 | 0.11–0.69 |
 SUV to union | 0.7 | 0.18–0.92 | 0.77 | 0.64–0.92 | 0.37 | 0.18–0.79 |
 Z-A to SUV | 0.88 | 0.15–0.99 | 0.88 | 0.75–0.97 | 0.59 | 0.15–0.99 |
 Z-B to Z-A | 0.83 | 0.59–0.99 | 0.89 | 0.79–0.99 | 0.63 | 0.59–0.95 |
 Reader B to A | 0.78 | 0.42–0.92 | 0.83 | 0.78–0.92 | 0.64 | 0.42–0.85 |
TPVF (%) | ||||||
 Z-A to reader A | 91.4 | 55.48–100.00 | 98.9 | 89.21–100.00 | 78.5 | 55.48–93.65 |
 Z-A to reader B | 80.5 | 18.22–99.91 | 96.3 | 70.18–99.91 | 62.0 | 18.22–94.05 |
 Z-A to intersection | 98.0 | 59.56–100.00 | 99.9 | 94.35–100.00 | 87.5 | 59.56–98.56 |
 Z-A to union | 77.8 | 17.86–99.92 | 96.0 | 70.82–99.92 | 77.8 | 17.86–90.34 |
 SUV to reader A | 99.4 | 34.64–100.00 | 99.8 | 99.34–100.00 | 96.6 | 34.64–100.00 |
 SUV to reader B | 92.0 | 31.92–99.63 | 96.7 | 72.27–99.63 | 84.8 | 31.92–96.95 |
 SUV to intersection | 100.0 | 53.19–100.00 | 100.0 | 99.83–100.00 | 99.8 | 53.19–100.00 |
 SUV to union | 95.4 | 24.64–99.91 | 96.4 | 73.04–99.91 | 95.3 | 24.64–97.28 |
 Z-A to SUV | 91.4 | 17.09–100.00 | 87.9 | 59.49–100.00 | 97.5 | 17.09–100.00 |
 Z-B to Z-A | 92.7 | 56.35–100.00 | 86.9 | 70.80–100.00 | 100.0 | 56.35–100.00 |
 Reader B to A | 81.4 | 50.25–98.10 | 88.5 | 79.06–98.10 | 71.1 | 50.25–93.15 |
1-FPVF(%) | ||||||
 Z-A to reader A | 68.8 | 40.61–88.04 | 74.5 | 40.61–84.70 | 61.3 | 55.79–88.04 |
 Z-A to reader B | 68.3 | 31.79–100.00 | 74.4 | 39.29–91.24 | 52.9 | 31.79–100.00 |
 Z-A to intersection | 62.7 | 30.95–88.04 | 70.8 | 32.51–79.93 | 47.9 | 30.95–88.04 |
 Z-A to union | 75.7 | 30.54–100.00 | 88.3 | 46.25–92.29 | 62.2 | 30.54–100.00 |
 SUV to reader A | 57.7 | 11.82–81.57 | 59.2 | 39.99–81.57 | 54.4 | 11.82–73.02 |
 SUV to reader B | 54.6 | 10.97–85.55 | 74.6 | 40.51–85.55 | 42.8 | 10.97–70.14 |
 SUV to intersection | 48.6 | 6.10–78.25 | 58.2 | 32.94–78.25 | 30.2 | 6.10–69.07 |
 SUV to union | 66.0 | 9.91–88.88 | 75.7 | 46.85–88.88 | 55.2 | 9.91–74.10 |
 Z-A to SUV | 100.0 | 8.36–100.00 | 100.0 | 77.01–100.00 | 100.0 | 8.36–100.00 |
 Z-B to Z-A | 87.3 | 44.02–100.00 | 90.3 | 86.36–100.00 | 61.5 | 44.02–89.62 |
 Reader B to A | 77.3 | 26.93–95.40 | 77.7 | 65.93–95.40 | 59.1 | 26.93–95.32 |