A semi-automatic technique to quantify complex tuberculous lung lesions on 18 F-fluorodeoxyglucose positron emission tomography/computerised tomography images

EJNMMI Research

Table 1 Study design for method development and pilot application

	Training set		Test set
Group	Negative controls	Positive controls	Negative controls	PTB cases
	n = 15	n = 5	n = 5	n = 5
PET-CT indication	Clinical	Observational cohort	Observational cohort	Observational cohort
Clinical background	Diagnostic work-up	PTB patients, after treatment	PTB contacts	PTB patients on treatment,
Scan time-points	Single scan	Single scan, after TB treatment	Single scan	Baseline, month 1 and month 6 of treatment
Lung scan findings	Lesion free	Minimal to mild intensity lesions after TB treatment	Lesion free	Extensive lesions
Main function of inclusion	Optimising Z-score threshold specificity	Optimising Z-score threshold sensitivity	Testing specificity	Pilot application