| Training set | Test set | ||
---|---|---|---|---|
Group | Negative controls | Positive controls | Negative controls | PTB cases |
 | n = 15 | n = 5 | n = 5 | n = 5 |
PET-CT indication | Clinical | Observational cohort | Observational cohort | Observational cohort |
Clinical background | Diagnostic work-up | PTB patients, after treatment | PTB contacts | PTB patients on treatment, |
Scan time-points | Single scan | Single scan, after TB treatment | Single scan | Baseline, month 1 and month 6 of treatment |
Lung scan findings | Lesion free | Minimal to mild intensity lesions after TB treatment | Lesion free | Extensive lesions |
Main function of inclusion | Optimising Z-score threshold specificity | Optimising Z-score threshold sensitivity | Testing specificity | Pilot application |