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Table 1 Distribution and kinetics of L- and D-18F-FBPA in normal rats

From: Evaluation of D-isomers of 4-borono-2-18F-fluoro-phenylalanine and O-11C-methyl-tyrosine as brain tumor imaging agents: a comparative PET study with their L-isomers in rat brain glioma

  Organs 1 min 5 min 10 min 30 min 60 min 90 min
Brain L 0.28 ± 0.20 0.29 ± 0.01 0.41 ± 0.02 0.60 ± 0.02 0.76 ± 0.05 0.77 ± 0.04
  D 0.15 ± 0.02 0.07 ± 0.01 0.05 ± 0.01 0.06 ± 0.01 0.07 ± 0.01 0.10 ± 0.01
Heart L 1.23 ± 0.08 1.10 ± 0.03 1.15 ± 0.05 1.17 ± 0.05 1.10 ± 0.04 1.00 ± 0.04
  D 0.95 ± 0.08 0.81 ± 0.04 0.36 ± 0.03 0.24 ± 0.02 0.20 ± 0.02 0.21 ± 0.01
Lung L 1.94 ± 0.25 1.56 ± 0.08 1.52 ± 0.15 1.20 ± 0.04 0.94 ± 0.02 0.92 ± 0.05
  D 1.92 ± 0.15 1.04 ± 0.07 0.75 ± 0.04 0.48 ± 0.03 0.34 ± 0.03 0.32 ± 0.01
Liver L 1.69 ± 0.06 2.01 ± 0.05 2.16 ± 0.05 1.68 ± 0.07 1.40 ± 0.04 1.27 ± 0.06
  D 1.16 ± 0.07 1.42 ± 0.04 1.64 ± 0.09 1.67 ± 0.04 1.19 ± 0.08 0.80 ± 0.04
Kidney L 10.56 ± 0.65 11.57 ± 0.69 10.88 ± 0.97 9.57 ± 0.47 9.11 ± 0.77 8.15 ± 0.62
  D 18.37 ± 1.13 37.61 ± 1.66 47.82 ± 1.17 38.30 ± 0.81 25.56 ± 3.32 19.97 ± 1.76
Spleen L 1.83 ± 0.07 2.08 ± 0.08 2.16 ± 0.21 1.77 ± 0.13 1.46 ± 0.04 1.33 ± 0.05
  D 0.88 ± 0.06 0.66 ± 0.04 0.44 ± 0.02 0.44 ± 0.01 0.43 ± 0.04 0.44 ± 0.02
Pancreas L 2.67 ± 0.35 2.80 ± 0.88 3.05 ± 0.29 2.40 ± 0.22 2.00 ± 0.24 1.75 ± 0.21
  D 1.08 ± 0.15 0.94 ± 0.14 1.24 ± 0.13 1.15 ± 0.08 0.80 ± 0.12 0.73 ± 0.04
Stomach L 1.26 ± 0.16 1.62 ± 1.05 1.14 ± 0.08 1.12 ± 0.08 0.94 ± 0.04 0.86 ± 0.05
  D 1.06 ± 0.07 0.81 ± 0.05 0.53 ± 0.06 0.35 ± 0.02 0.28 ± 0.04 0.28 ± 0.02
S. intestine L 1.64 ± 0.09 1.51 ± 0.07 1.58 ± 0.04 1.33 ± 0.08 1.20 ± 0.06 1.08 ± 0.07
  D 0.90 ± 0.02 0.51 ± 0.02 0.50 ± 0.04 0.69 ± 0.06 0.78 ± 0.03 0.73 ± 0.07
Colon L 0.73 ± 0.19 0.51 ± 0.04 0.61 ± 0.08 0.62 ± 0.08 0.57 ± 0.01 0.54 ± 0.02
  D 0.48 ± 0.04 0.33 ± 0.03 0.26 ± 0.03 0.16 ± 0.01 0.15 ± 0.02 0.15 ± 0.03
Bladder L 0.85 ± 0.19 1.29 ± 0.12 1.17 ± 0.22 1.60 ± 0.46 1.75 ± 0.33 1.84 ± 0.33
  D 0.98 ± 0.26 1.46 ± 0.24 1.92 ± 0.63 5.16 ± 2.13 4.79 ± 2.37 4.46 ± 1.82
Bone L 1.00 ± 0.09 1.05 ± 0.05 1.09 ± 0.04 1.04 ± 0.09 0.97 ± 0.01 0.94 ± 0.04
  D 1.01 ± 0.09 1.01 ± 0.05 0.71 ± 0.03 0.70 ± 0.03 0.61 ± 0.02 0.57 ± 0.01
Muscle L 0.33 ± 0.02 0.36 ± 0.02 0.48 ± 0.01 0.65 ± 0.05 0.75 ± 0.02 0.78 ± 0.04
  D 0.28 ± 0.06 0.27 ± 0.03 0.22 ± 0.01 0.12 ± 0.01 0.09 ± 0.01 0.11 ± 0.01
Blood L 2.96 ± 0.04 2.09 ± 0.04 1.86 ± 0.02 1.03 ± 0.04 1.10 ± 0.02 0.99 ± 0.05
  D 0.55 ± 0.06 1.15 ± 0.07 0.84 ± 0.05 0.56 ± 0.02 0.42 ± 0.03 0.38 ± 0.01
  1. Rats (n = 5/each time point) were injected intravenously with 5 MBq of L- or D-18F-FBPA via the tail vein and killed at each time point after the injection; tissue samples were rapidly removed, and their weights and radioactivities were measured. Data are expressed as mean ± SD of SUV