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Table 1 Distribution and kinetics of L- and D-18F-FBPA in normal rats

From: Evaluation of D-isomers of 4-borono-2-18F-fluoro-phenylalanine and O-11C-methyl-tyrosine as brain tumor imaging agents: a comparative PET study with their L-isomers in rat brain glioma

 

Organs

1 min

5 min

10 min

30 min

60 min

90 min

Brain

L

0.28 ± 0.20

0.29 ± 0.01

0.41 ± 0.02

0.60 ± 0.02

0.76 ± 0.05

0.77 ± 0.04

 

D

0.15 ± 0.02

0.07 ± 0.01

0.05 ± 0.01

0.06 ± 0.01

0.07 ± 0.01

0.10 ± 0.01

Heart

L

1.23 ± 0.08

1.10 ± 0.03

1.15 ± 0.05

1.17 ± 0.05

1.10 ± 0.04

1.00 ± 0.04

 

D

0.95 ± 0.08

0.81 ± 0.04

0.36 ± 0.03

0.24 ± 0.02

0.20 ± 0.02

0.21 ± 0.01

Lung

L

1.94 ± 0.25

1.56 ± 0.08

1.52 ± 0.15

1.20 ± 0.04

0.94 ± 0.02

0.92 ± 0.05

 

D

1.92 ± 0.15

1.04 ± 0.07

0.75 ± 0.04

0.48 ± 0.03

0.34 ± 0.03

0.32 ± 0.01

Liver

L

1.69 ± 0.06

2.01 ± 0.05

2.16 ± 0.05

1.68 ± 0.07

1.40 ± 0.04

1.27 ± 0.06

 

D

1.16 ± 0.07

1.42 ± 0.04

1.64 ± 0.09

1.67 ± 0.04

1.19 ± 0.08

0.80 ± 0.04

Kidney

L

10.56 ± 0.65

11.57 ± 0.69

10.88 ± 0.97

9.57 ± 0.47

9.11 ± 0.77

8.15 ± 0.62

 

D

18.37 ± 1.13

37.61 ± 1.66

47.82 ± 1.17

38.30 ± 0.81

25.56 ± 3.32

19.97 ± 1.76

Spleen

L

1.83 ± 0.07

2.08 ± 0.08

2.16 ± 0.21

1.77 ± 0.13

1.46 ± 0.04

1.33 ± 0.05

 

D

0.88 ± 0.06

0.66 ± 0.04

0.44 ± 0.02

0.44 ± 0.01

0.43 ± 0.04

0.44 ± 0.02

Pancreas

L

2.67 ± 0.35

2.80 ± 0.88

3.05 ± 0.29

2.40 ± 0.22

2.00 ± 0.24

1.75 ± 0.21

 

D

1.08 ± 0.15

0.94 ± 0.14

1.24 ± 0.13

1.15 ± 0.08

0.80 ± 0.12

0.73 ± 0.04

Stomach

L

1.26 ± 0.16

1.62 ± 1.05

1.14 ± 0.08

1.12 ± 0.08

0.94 ± 0.04

0.86 ± 0.05

 

D

1.06 ± 0.07

0.81 ± 0.05

0.53 ± 0.06

0.35 ± 0.02

0.28 ± 0.04

0.28 ± 0.02

S. intestine

L

1.64 ± 0.09

1.51 ± 0.07

1.58 ± 0.04

1.33 ± 0.08

1.20 ± 0.06

1.08 ± 0.07

 

D

0.90 ± 0.02

0.51 ± 0.02

0.50 ± 0.04

0.69 ± 0.06

0.78 ± 0.03

0.73 ± 0.07

Colon

L

0.73 ± 0.19

0.51 ± 0.04

0.61 ± 0.08

0.62 ± 0.08

0.57 ± 0.01

0.54 ± 0.02

 

D

0.48 ± 0.04

0.33 ± 0.03

0.26 ± 0.03

0.16 ± 0.01

0.15 ± 0.02

0.15 ± 0.03

Bladder

L

0.85 ± 0.19

1.29 ± 0.12

1.17 ± 0.22

1.60 ± 0.46

1.75 ± 0.33

1.84 ± 0.33

 

D

0.98 ± 0.26

1.46 ± 0.24

1.92 ± 0.63

5.16 ± 2.13

4.79 ± 2.37

4.46 ± 1.82

Bone

L

1.00 ± 0.09

1.05 ± 0.05

1.09 ± 0.04

1.04 ± 0.09

0.97 ± 0.01

0.94 ± 0.04

 

D

1.01 ± 0.09

1.01 ± 0.05

0.71 ± 0.03

0.70 ± 0.03

0.61 ± 0.02

0.57 ± 0.01

Muscle

L

0.33 ± 0.02

0.36 ± 0.02

0.48 ± 0.01

0.65 ± 0.05

0.75 ± 0.02

0.78 ± 0.04

 

D

0.28 ± 0.06

0.27 ± 0.03

0.22 ± 0.01

0.12 ± 0.01

0.09 ± 0.01

0.11 ± 0.01

Blood

L

2.96 ± 0.04

2.09 ± 0.04

1.86 ± 0.02

1.03 ± 0.04

1.10 ± 0.02

0.99 ± 0.05

 

D

0.55 ± 0.06

1.15 ± 0.07

0.84 ± 0.05

0.56 ± 0.02

0.42 ± 0.03

0.38 ± 0.01

  1. Rats (n = 5/each time point) were injected intravenously with 5 MBq of L- or D-18F-FBPA via the tail vein and killed at each time point after the injection; tissue samples were rapidly removed, and their weights and radioactivities were measured. Data are expressed as mean ± SD of SUV