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Fig. 5 | EJNMMI Research

Fig. 5

From: Evaluation of D-isomers of 4-borono-2-18F-fluoro-phenylalanine and O-11C-methyl-tyrosine as brain tumor imaging agents: a comparative PET study with their L-isomers in rat brain glioma

Fig. 5

Ex vivo autoradiography and histochemical imaging of C6 glioma-bearing rat brains. After PET imaging using L- (a) or D-18F-FBPA (b), rats were sacrificed under anesthesia, the brain was excised and sliced at a thickness of 2 mm, and the slices were then exposed to a phosphoimaging plate in order to calculate the target tumor (glioma) to non-target (normal) ratios of L- and D-18F-FBPA (c). #P < 0.05 vs. L-isomer. The brain excised from another rat bearing C6 glioma was fixed in 4% neutral-buffered formalin; samples were embedded in paraffin, sliced at a thickness of 30 μm, and stained with HE (d)

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