Fig. 3

Statistical significance maps rendered on axial slices and semi-inflated surface showing increase in ¹¹C-PBR28 binding in unmedicated depressed patients compared to healthy controls (a). b The same analysis is restricted to high-affinity binder subjects, done with the more stringent threshold of p < 0.001. Only clusters with threshold p < 0.05 for cluster-wise multiple comparisons are displayed. The color bar represents T values. The same comparison using only mixed-affinity binders yielded no significant differences, but the unmedicated group comprised only two mixed-affinity binders