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Fig. 6 | EJNMMI Research

Fig. 6

From: Effect of starvation on brain glucose metabolism and 18F-2-fluoro-2-deoxyglucose uptake: an experimental in-vivo and ex-vivo study

Fig. 6

Theoretical model of FDG uptake in the brain and skeletal muscle. This cartoon represents a theoretical model for FDG uptake in the brain and skeletal muscles in control (green) and STS (blue) mice. a FDG arterial concentration as predicted by the corresponding average clearance value measured in the two groups: the decreased tracer sequestration by the whole body prolongs tracer availability in the bloodstream. b The instantaneous uptake (KBq × min−1). The curves are defined assuming an identical flow rate in the two conditions, with final uptake values only justified by the interaction between extraction fraction and tracer availability. The brain and skeletal muscle are represented by solid and dotted lines, respectively. c Time-concentration curves in the two tissues and points out the progressive increase in STS brain as a consequence of the prolonged tracer availability. Despite a virtual halving of extraction fraction, the prolonged uptake phase eventually results in preserved FDG uptake a later time. This phenomenon is markedly less evident in the skeletal muscle due to the relatively more severe (fivefold vs twofold) reduction in glucose consumption

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