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Table 5 Changes in metabolic tumor activity for the VOIman during the neoadjuvant treatment between 18F-FDG PET-CT scans 1 and 3, combined with the corresponding histopathologic tumor response for each patient

From: Volume of interest delineation techniques for 18F-FDG PET-CT scans during neoadjuvant extremity soft tissue sarcoma treatment in adults: a feasibility study

Patient number Scan 1 vs. 3 SUVmax Scan 1 vs. 3 SUVpeak Scan 1 vs. 3 SUVmean Scan 1 vs. 3 TLG Scan 1 vs. 3 MATV (ml) EORTC-STBSG response grade [26]
  Δ Δ % Δ Δ % Δ Δ % Δ Δ % Δ Δ %  
1 − 0.5 − 32.0 − 0.4 − 27.0 − 0.2 − 22.4 − 44.4 − 79.2 − 38.0 − 73.1 C
2 0.1 5.2 − 0.0 − 1.7 0.0 − 0.7 − 4.4 − 36.3 − 6.4 − 35.8 D
3 − 2.0 − 36.6 − 2.0 − 40.7 − 1.3 − 54.6 − 578.1 − 51.9 27.9 5.9 D
4 − 4.8 − 32.7 − 4.9 − 37.6 − 3.1 − 65.1 − 1986.4 − 74.3 − 150.4 − 26.5 D
5 − 6.6 − 75.0 − 5.7 − 76.2 −  1.2 − 47.6 − 165.7 − 81.8 − 54.4 − 65.2 A
6 − 0.5 − 15.0 − 0.2 − 6.4 0.1 5.0 53.8 49.5 27.5 42.4 E
7 − 3.2 − 59.0 − 2.5 − 56.5 − 0.7 − 40.6 − 883.9 − 38.8 38.6 3.1 D
8 − 18.2 − 83.8 − 17.3 − 87.3 − 5.2 − 83.7 − 658.4 − 85.4 − 12.8 − 10.3 B
9 − 3.2 − 46.5 − 3.2 − 49.5 − 0.8 − 25.5 − 278.7 − 60.7 − 73.5 − 47.3 D
10 NA NA NA NA NA NA NA NA NA NA E
11 − 7.0 − 73.1 − 6.3 − 73.8 − 2.0 − 54.4 − 291.3 − 91.7 − 69.6 − 81.9 C
  1. Histopathologic responders are indicated in gray. A percentage difference of > 75% in TLG seemed to identify the histopathologic responders; these values were encircled
  2. 18F-FDG PET-CT fluorine-18-fluorodeoxyglucose positron emission tomography with computed tomography, SUV max maximum standardized uptake value, SUV peak peak standardized uptake value, SUV mean mean standardized uptake value, TLG total lesion glycolysis, MATV metabolically active tumor volume, EORTC-STBSG European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group