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Table 4 Changes in metabolic tumor activity for the VOIman during the neoadjuvant treatment between the serial 18F-FDG PET-CT scans

From: Volume of interest delineation techniques for 18F-FDG PET-CT scans during neoadjuvant extremity soft tissue sarcoma treatment in adults: a feasibility study

Parameter Scan 1 vs. 2 Scan 2 vs. 3 Scan 1 vs. 3
  Δ Δ % Δ Δ % Δ Δ %
SUVmax − 2.6 (− 6.4 to − 0.5)# − 37.7 (− 67.7 to − 16.4) − 0.3 (− 0.5 to − 0.1) − 13.6 (− 17.5 to − 4.7) − 3.2 (− 6.7 to − 0.5)# − 41.6 (− 73.5 to − 27.7)
SUVpeak −2.8 (− 5.6 to − 0.4)# − 45.8 (− 67.4 to − 17.3) − 0.2 (− 0.5 to 0.0) − 9.3 (− 16.8 to 0.4) − 2.9 (− 5.9 to − 0.3)# − 45.1 (− 74.4 to − 21.9)
SUVmean − 0.9 (− 1.9 to − 0.1)# − 39.3 (− 52.0 to − 13.2) − 0.1 (− 0.2 to 0.0) − 4.6 (− 17.2 to 2.3) − 1.0 (− 2.3 to − 0.2)# − 44.1 (− 57.2 to − 17.0)
TLG − 233.6 (− 637.9 to − 28.0)* − 52.6 (− 73.6 to − 36.3) − 18.4 (− 57.0 to − 10.6)# − 16.3 (− 59.7 to − 5.5) − 285.0 (− 714.7 to − 34.4)* − 67.5 (− 82.6 to − 38.2)
MATV (ml) − 22.1 (− 48.2 to 33.5) − 7.5 (− 44.9 to 23.5) − 13.2 (− 53.0 to − 5.3)# − 19.8 (− 49.4 to − 2.7) − 25.4 (− 70.6 to 27.6) − 31.2 (− 67.2 to 3.8)
  1. Data presented as median (IQR)
  2. VOI volume of interest, VOI man manually drawn VOI, 18F-FDG PET-CT fluorine-18-fluorodeoxyglucose positron emission tomography with computed tomography, SUV max maximum standardized uptake value, SUV peak peak standardized uptake value, SUV mean mean standardized uptake value, TLG total lesion glycolysis, MATV metabolically active tumor volume, IQR interquartile range. *p < 0.05; #p < 0.01
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