Volume of interest delineation techniques for 18F-FDG PET-CT scans during neoadjuvant extremity soft tissue sarcoma treatment in adults: a feasibility study

EJNMMI Research

Table 2 Spearman’s correlation between the VOI_man and VOI_{auto/grad/grad+} for the serial ¹⁸F-FDG PET-CT scans

Parameter	Scan 1		Scan 2		Scan 3
	Correlation coefficient	p value	Correlation coefficient	p value	Correlation coefficient	p value
SUV_max
VOI_man-auto	1.000	NA	1.000	NA	0.988	< 0.001
VOI_man-grad	1.000	NA	1.000	NA	1.000	NA
VOI_man-grad+	1.000	NA	1.000	NA	1.000	NA
SUV_peak
VOI_man-auto	1.000	NA	1.000	NA	0.988	< 0.001
VOI_man-grad	1.000	NA	1.000	NA	1.000	NA
VOI_man-grad+	1.000	NA	1.000	NA	1.000	NA
SUV_mean
VOI_man-auto	0.964	< 0.001	0.836	0.001	0.564	0.090
VOI_man-grad	0.991	< 0.001	0.882	< 0.001	0.758	0.011
VOI_man-grad+	0.991	< 0.001	0.982	< 0.001	0.988	< 0.001
TLG
VOI_man-auto	0.845	0.001	0.982	< 0.001	0.842	0.002
VOI_man-grad	0.991	< 0.001	1.000	NA	0.976	< 0.001
VOI_man-grad+	0.991	< 0.001	0.991	< 0.001	0.988	< 0.001
MATV
VOI_man-auto	0.309	0.355	0.555	0.077	0.430	0.214
VOI_man-grad	0.955	< 0.001	0.973	< 0.001	0.806	0.005
VOI_man-grad+	0.936	< 0.001	1.000	NA	0.964	< 0.001

Spearman’s test for correlations was used to calculate significance. The strongest correlation for the three PET scans was found between the VOI_man and the VOI_grad+, as indicated in gray
VOI volume of interest, VOI_man manually drawn VOI, VOI_auto automatically drawn VOI, VOI_grad VOI based on the gradient between voxels, VOI_grad+ VOI_grad + necrosis, ¹⁸F-FDG PET-CT fluorine-18-fluorodeoxyglucose positron emission tomography with computed tomography, SUV_max maximum standardized uptake value, SUV_peak peak standardized uptake value, SUV_mean mean standardized uptake value, TLG total lesion glycolysis, MATV metabolically active tumor volume, IQR interquartile range, NA not applicable