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Table 2 Spearman’s correlation between the VOIman and VOIauto/grad/grad+ for the serial 18F-FDG PET-CT scans

From: Volume of interest delineation techniques for 18F-FDG PET-CT scans during neoadjuvant extremity soft tissue sarcoma treatment in adults: a feasibility study

Parameter Scan 1 Scan 2 Scan 3
  Correlation coefficient p value Correlation coefficient p value Correlation coefficient p value
SUVmax
 VOIman-auto 1.000 NA 1.000 NA 0.988 < 0.001
 VOIman-grad 1.000 NA 1.000 NA 1.000 NA
 VOIman-grad+ 1.000 NA 1.000 NA 1.000 NA
SUVpeak
 VOIman-auto 1.000 NA 1.000 NA 0.988 < 0.001
 VOIman-grad 1.000 NA 1.000 NA 1.000 NA
 VOIman-grad+ 1.000 NA 1.000 NA 1.000 NA
SUVmean
 VOIman-auto 0.964 < 0.001 0.836 0.001 0.564 0.090
 VOIman-grad 0.991 < 0.001 0.882 < 0.001 0.758 0.011
 VOIman-grad+ 0.991 < 0.001 0.982 < 0.001 0.988 < 0.001
TLG
 VOIman-auto 0.845 0.001 0.982 < 0.001 0.842 0.002
 VOIman-grad 0.991 < 0.001 1.000 NA 0.976 < 0.001
 VOIman-grad+ 0.991 < 0.001 0.991 < 0.001 0.988 < 0.001
MATV
 VOIman-auto 0.309 0.355 0.555 0.077 0.430 0.214
 VOIman-grad 0.955 < 0.001 0.973 < 0.001 0.806 0.005
 VOIman-grad+ 0.936 < 0.001 1.000 NA 0.964 < 0.001
  1. Spearman’s test for correlations was used to calculate significance. The strongest correlation for the three PET scans was found between the VOIman and the VOIgrad+, as indicated in gray
  2. VOI volume of interest, VOI man manually drawn VOI, VOI auto automatically drawn VOI, VOI grad VOI based on the gradient between voxels, VOI grad+ VOIgrad + necrosis, 18F-FDG PET-CT fluorine-18-fluorodeoxyglucose positron emission tomography with computed tomography, SUV max maximum standardized uptake value, SUV peak peak standardized uptake value, SUV mean mean standardized uptake value, TLG total lesion glycolysis, MATV metabolically active tumor volume, IQR interquartile range, NA not applicable