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Table 2 Histological analysis of the liver in mice fed a CDAHFD

From: Evaluation of hepatic integrin αvβ3 expression in non-alcoholic steatohepatitis (NASH) model mouse by 18F-FPP-RGD2 PET

Parameter Control 3 weeks CDAHFD 3 weeks Control 8 weeks CDAHFD 8 weeks
Steatosis score 0.00 ± 0.00 1.75 ± 0.71** 0.00 ± 0.00 1.88 ± 0.35**
Inflammation score 0.00 ± 0.00 2.88 ± 0.35** 0.00 ± 0.00 3.00 ± 0.00**
Ballooning score 0.00 ± 0.00 0.38 ± 0.52** 0.00 ± 0.00 0.88 ± 0.64**
NAFLD activity score 0.00 ± 0.00 5.00 ± 1.07** 0.00 ± 0.00 5.75 ± 0.71**
Fibrosis area (%) 0.61 ± 0.29 0.47 ± 0.19 0.65 ± 0.18 3.89 ± 1.81**##
  1. Representative photomicrographs of hepatic histology stained with hematoxylin and eosin (H&E) and Sirius red. Steatosis and inflammation scores ranged from 0 to 3 (normal = 0; minimal = 1; moderate = 2; marked = 3). Ballooning score ranged from 0 to 2 (normal = 0; minimal = 1; marked = 2). NAFLD activity score (NAS) was calculated by using the sum of each histological score. Data are expressed as the mean ± SD (n = 8 mice per group). Statistical differences were assessed using Steel-Dwass test. Hematoxylin and eosin (H&E) and Sirius red, × 200 magnification
  2. *p < 0.05, **p < 0.01 compared with respective control mice. ##p < 0.01 compared with CDAHFD 3 weeks