| [11C]1 | [18F]2 |
---|
| Mouse | Rat | Mouse | Rat |
---|
15 min |
Intact (%) | 56 ± 14 | 65 ± 7 | 20 ± 1 | 1 ± 1 |
Non-polar (%) | 24 ± 15 | 13 ± 4 | 76 ± 3 | 98 ± 1 |
Polar (%) | 20 ± 5 | 21 ± 3 | 1 ± 0.2 | 2 ± 0 |
45 min |
Intact (%) | 24 ± 1 | 29 ± 11 | 3 ± 2 | 0 ± 0* |
Non-polar (%) | 28 ± 8 | 6 ± 3 | 95 ± 2 | 92 ± 3* |
Polar (%) | 47 ± 7 | 65 ± 12 | 2 ± 1 | 8 ± 3* |
- Following i.v. administration in healthy animals, anaesthetised using isoflurane, blood plasma was obtained at 15 and 45 min. Blood plasma was separated into a polar and non-polar fraction using a SPE method. Non polar fractions were analysed on HPLC. Results are expressed as average percentage of total blood plasma activity ± standard deviation (n = at least three per data point). *Animals were sacrificed at 60 min post injection.