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Table 2 Plasma metabolite profile of [11C]1 and [18F]2 following i.v. administration in healthy SCID mice and previously obtained results following i.v. administration in healthy Wistar rats [19, 20]

From: In vivo evaluation of two tissue transglutaminase PET tracers in an orthotopic tumour xenograft model

  [11C]1 [18F]2
  Mouse Rat Mouse Rat
15 min
 Intact (%) 56 ± 14 65 ± 7 20 ± 1 1 ± 1
 Non-polar (%) 24 ± 15 13 ± 4 76 ± 3 98 ± 1
 Polar (%) 20 ± 5 21 ± 3 1 ± 0.2 2 ± 0
45 min
 Intact (%) 24 ± 1 29 ± 11 3 ± 2 0 ± 0*
 Non-polar (%) 28 ± 8 6 ± 3 95 ± 2 92 ± 3*
 Polar (%) 47 ± 7 65 ± 12 2 ± 1 8 ± 3*
  1. Following i.v. administration in healthy animals, anaesthetised using isoflurane, blood plasma was obtained at 15 and 45 min. Blood plasma was separated into a polar and non-polar fraction using a SPE method. Non polar fractions were analysed on HPLC. Results are expressed as average percentage of total blood plasma activity ± standard deviation (n = at least three per data point). *Animals were sacrificed at 60 min post injection.