|
[11C]1
|
[18F]2
|
---|
|
Mouse
|
Rat
|
Mouse
|
Rat
|
---|
15 min
|
Intact (%)
|
56 ± 14
|
65 ± 7
|
20 ± 1
|
1 ± 1
|
Non-polar (%)
|
24 ± 15
|
13 ± 4
|
76 ± 3
|
98 ± 1
|
Polar (%)
|
20 ± 5
|
21 ± 3
|
1 ± 0.2
|
2 ± 0
|
45 min
|
Intact (%)
|
24 ± 1
|
29 ± 11
|
3 ± 2
|
0 ± 0*
|
Non-polar (%)
|
28 ± 8
|
6 ± 3
|
95 ± 2
|
92 ± 3*
|
Polar (%)
|
47 ± 7
|
65 ± 12
|
2 ± 1
|
8 ± 3*
|
- Following i.v. administration in healthy animals, anaesthetised using isoflurane, blood plasma was obtained at 15 and 45 min. Blood plasma was separated into a polar and non-polar fraction using a SPE method. Non polar fractions were analysed on HPLC. Results are expressed as average percentage of total blood plasma activity ± standard deviation (n = at least three per data point). *Animals were sacrificed at 60 min post injection.