Fig. 1
From: Treatment response assessment with (R)-[11CPAQ PET in the MMTV-PyMT mouse model of breast cancer
Therapy response assessments in PyMT mice with (R)-[11C]aPAQ PET imaging. The (R)-[11C]PAQ uptake in PyMT mouse a, b before (baseline, day 0) and c, d 4 days after B20-4.1.1/PTX combinational treatment (shown as example). The twofold magnified boxed areas (a, c upper and lower images) show transverse plane through the corresponding mammary tumors area (red dotted circles). The white dashed areas on b and d represent the mammary tumor areas, included in PET/MRI analyses. PG, parotid glands; A, abdomen; B, bladder. All images are scaled to the same color scale. Quantification summary of (R)-[11C]PAQ uptake e SUVmean and f SUVmax values as a percentage of change from baseline, day 0 to day 4 in all treatment groups (n = 11–12 tumors/group). The comparisons between the groups are shown (Kruskal-Wallis test, *p < 0.05 and **p < 0.01). Each individual tumor is presented as a dot. The horizontal lines indicate the median values