Table 5 Effect of safety margins on tumor coverage
N = 9 | Volume of tumor segmentation with a 5-mm safety margin (mL) | Underestimated volume of tumor despite a 5-mm safety margin (mL) | Percentage of underestimated tumor volume despite a 5-mm safety margin (%) | Volume of tumor segmentation with a 10-mm safety margin (mL) | Underestimated volume of tumor despite a 10-mm safety margin (mL) | Percentage of underestimated tumor volume despite a 10-mm safety margin (%) | Minimum necessary safety margin to ensure complete coverage (mm) |
|---|---|---|---|---|---|---|---|
Reader 1 (seg1) | 4.83 ± 3.97 [3.48; 1.81–13.7] | 0.27 ± 0.24 [0.3; 0.0–0.6] | 14.6 ± 15.7 [8.4; 0.0–47.6] | 11.01 ± 6.33 [9.61; 5.43–24.94] | 0.11 ± 0.32 [0.0; 0.0–0.95] | 1.91 ± 4.74 [0.0; 0.0–14.29] | 8.78 ± 3.63 [9.0; 2.0–15.0] |
Reader 2 (seg2) | 4.55 ± 1.72 [5.15; 1.66–6.99] | 0.57 ± 0.72 [0.2; 0.0–1.8] | 19.2 ± 15.9 [19.6; 0.0–49.1] | 10.67 ± 3.19 [11.33; 5.09–15.95] | 0.13 ± 0.25 [0.01; 0.0–0.77] | 3.60 ± 6.74 [0.72; 0.0–20.64] | 9.67 ± 3.71 [11.0; 3.0–15.0] |
18F-Choline PETEdge (seg3) | 7.42 ± 6.62 [6.06; 1.94–24.15] | 0.15 ± 0.19 [0.02; 0.0–0.48] | 7.61 ± 10.2 [3.5; 0.0–31.2] | 14.27 ± 8.40 [12.47; 5.46–34.38] | 0.004 ± 0.013 [0.0; 0.0–0.04] | 0.15 ± 0.46 [0.0; 0.0–1.38] | 7.33 ± 2.78 [7.0; 3.0–11.0] |
Combined (seg4) | 8.88 ± 6.50 [7.1; 2.44–24.83] | 0.03 ± 0.05 [0.02; 0.0–0.14] | 2.04 ± 2.84 [0.54; 0.0–8.0] *P = 0.03 # P = 0.01 | 16.07 ± 8.06 [14.17; 6.58–35.35] | 0.0 ± 0.0 [0.0; 0.0–0.0] | 0.0 ± 0.0 [0.0; 0.0–0.0] | 6.00 ± 1.87 [5.0; 3.0–9.0] |