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Table 5 Effect of safety margins on tumor coverage

From: Accuracy of tumor segmentation from multi-parametric prostate MRI and 18F-choline PET/CT for focal prostate cancer therapy applications

N = 9 Volume of tumor segmentation with a 5-mm safety margin (mL) Underestimated volume of tumor despite a 5-mm safety margin (mL) Percentage of underestimated tumor volume despite a 5-mm safety margin (%) Volume of tumor segmentation with a 10-mm safety margin (mL) Underestimated volume of tumor despite a 10-mm safety margin (mL) Percentage of underestimated tumor volume despite a 10-mm safety margin (%) Minimum necessary safety margin to ensure complete coverage (mm)
Reader 1 (seg1) 4.83 ± 3.97 [3.48; 1.81–13.7] 0.27 ± 0.24 [0.3; 0.0–0.6] 14.6 ± 15.7 [8.4; 0.0–47.6] 11.01 ± 6.33 [9.61; 5.43–24.94] 0.11 ± 0.32 [0.0; 0.0–0.95] 1.91 ± 4.74 [0.0; 0.0–14.29] 8.78 ± 3.63 [9.0; 2.0–15.0]
Reader 2 (seg2) 4.55 ± 1.72 [5.15; 1.66–6.99] 0.57 ± 0.72 [0.2; 0.0–1.8] 19.2 ± 15.9 [19.6; 0.0–49.1] 10.67 ± 3.19 [11.33; 5.09–15.95] 0.13 ± 0.25 [0.01; 0.0–0.77] 3.60 ± 6.74 [0.72; 0.0–20.64] 9.67 ± 3.71 [11.0; 3.0–15.0]
18F-Choline PETEdge (seg3) 7.42 ± 6.62 [6.06; 1.94–24.15] 0.15 ± 0.19 [0.02; 0.0–0.48] 7.61 ± 10.2 [3.5; 0.0–31.2] 14.27 ± 8.40 [12.47; 5.46–34.38] 0.004 ± 0.013 [0.0; 0.0–0.04] 0.15 ± 0.46 [0.0; 0.0–1.38] 7.33 ± 2.78 [7.0; 3.0–11.0]
Combined (seg4) 8.88 ± 6.50 [7.1; 2.44–24.83] 0.03 ± 0.05 [0.02; 0.0–0.14] 2.04 ± 2.84 [0.54; 0.0–8.0]
*P = 0.03
# P = 0.01
16.07 ± 8.06 [14.17; 6.58–35.35] 0.0 ± 0.0 [0.0; 0.0–0.0] 0.0 ± 0.0 [0.0; 0.0–0.0] 6.00 ± 1.87 [5.0; 3.0–9.0]
  1. Mean ± standard deviation [median; minimum–maximum range]
  2. VOI volume of interest
  3. *Combined vs. reader 1
  4. #Combined vs. reader 2