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EJNMMI Research

Table 3 Agreement of manual and semi-automated tumor segmentation with histology

From: Accuracy of tumor segmentation from multi-parametric prostate MRI and 18F-choline PET/CT for focal prostate cancer therapy applications

N = 9

Reference histological volume (mL)

Ellipsoid-based tumor volume estimate (mL)

Segmented tumor volume (mL)

Underestimated tumor volume (mL)

Underestimated tumor volume (mL) in % of histological volume

HD (mm)

MDA (mm)

Dice

Jaccard

Reader 1 (seg1)

2.06 ± 1.95 [1.37; 0.19–6.31]

1.14 ± 1.26 [0.69; 0.08–3.97]

0.59 ± 0.79 [0.27; 0.07–2.53]

1.55 ± 1.22 [1.19; 0.12–3.77]

78.7 ± 15.9 [78.1; 52.6–94.7]

9.33 ± 3.84 [8.83; 2.2–15.7]

2.79 ± 1.51 [2.37; 0.56–5.5]

0.35 ± 0.20 [0.44; 0.09–0.61]

0.22 ± 0.14 [0.28; 0.05–0.44]

Reader 2 (seg2)

0.93 ± 0.58 [0.86; 0.23–1.96]

0.50 ± 0.36 [0.32; 0.15–1.17]

1.82 ± 1.75 [1.17; 0.2–5.54]

80.1 ± 14.0 [84.78; 61.3–98.6]

10.69 ± 4.12 [11.5;3.7–15.8]

3.15 ± 1.50 [3.15; 1.0–4.95]

0.30 ± 0.15 [0.28; 0.07–0.53]

0.19 ± 0.11 [0.16; 0.03–0.36]

18F-Choline PETEdge (seg3)

2.36 ± 4.19 [1.09; 0.28–13.39]

1.67 ± 3.07 [0.84; 0.15–9.75]

1.05 ± 0.80 [0.93; 0.16–2.54]

57.5 ± 17.9 [56.1; 21.1–79.0]

8.86 ± 2.72 [9.28; 3.6–12.5]

2.12 ± 0.63 [2.27; 0.93–3.11]

0.49 ± 0.11 [0.51; 0.32–0.63]

0.33 ± 0.09 [0.35; 0.19–0.46]

Combined (seg4)

N/A

2.28 ± 3.03 [1.55; 0.26–10.17]

0.71 ± 0.71 [0.36; 0.07–2.07]

42.4 ± 22.1 [39.7; 3.17–72.5]

*p = 0.004

#P = 0.002

8.11 ± 2.67 [8.64; 3.6–12.0]

1.84 ± 0.72 [1.75; 0.78–3.0]

0.52 ± 0.13 [0.56; 0.3–0.66]

0.36 ± 0.11 [0.39; 0.18–0.49]

*p = 0.05

#P = 0.005

  1. Mean ± standard deviation [median; minimum–maximum range]
  2. VOI volume of interest, HD Hausdorff distance, MDA mean distance to agreement, N/A not applicable
  3. *Combined (seg4) vs. reader 1 (seg1)
  4. #Combined (seg4) vs. reader 2 (seg2)
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