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Table 3 Agreement of manual and semi-automated tumor segmentation with histology

From: Accuracy of tumor segmentation from multi-parametric prostate MRI and 18F-choline PET/CT for focal prostate cancer therapy applications

N = 9 Reference histological volume (mL) Ellipsoid-based tumor volume estimate (mL) Segmented tumor volume (mL) Underestimated tumor volume (mL) Underestimated tumor volume (mL) in % of histological volume HD (mm) MDA (mm) Dice Jaccard
Reader 1 (seg1) 2.06 ± 1.95 [1.37; 0.19–6.31] 1.14 ± 1.26 [0.69; 0.08–3.97] 0.59 ± 0.79 [0.27; 0.07–2.53] 1.55 ± 1.22 [1.19; 0.12–3.77] 78.7 ± 15.9 [78.1; 52.6–94.7] 9.33 ± 3.84 [8.83; 2.2–15.7] 2.79 ± 1.51 [2.37; 0.56–5.5] 0.35 ± 0.20 [0.44; 0.09–0.61] 0.22 ± 0.14 [0.28; 0.05–0.44]
Reader 2 (seg2) 0.93 ± 0.58 [0.86; 0.23–1.96] 0.50 ± 0.36 [0.32; 0.15–1.17] 1.82 ± 1.75 [1.17; 0.2–5.54] 80.1 ± 14.0 [84.78; 61.3–98.6] 10.69 ± 4.12 [11.5;3.7–15.8] 3.15 ± 1.50 [3.15; 1.0–4.95] 0.30 ± 0.15 [0.28; 0.07–0.53] 0.19 ± 0.11 [0.16; 0.03–0.36]
18F-Choline PETEdge (seg3) 2.36 ± 4.19 [1.09; 0.28–13.39] 1.67 ± 3.07 [0.84; 0.15–9.75] 1.05 ± 0.80 [0.93; 0.16–2.54] 57.5 ± 17.9 [56.1; 21.1–79.0] 8.86 ± 2.72 [9.28; 3.6–12.5] 2.12 ± 0.63 [2.27; 0.93–3.11] 0.49 ± 0.11 [0.51; 0.32–0.63] 0.33 ± 0.09 [0.35; 0.19–0.46]
Combined (seg4) N/A 2.28 ± 3.03 [1.55; 0.26–10.17] 0.71 ± 0.71 [0.36; 0.07–2.07] 42.4 ± 22.1 [39.7; 3.17–72.5]
*p = 0.004
#P = 0.002
8.11 ± 2.67 [8.64; 3.6–12.0] 1.84 ± 0.72 [1.75; 0.78–3.0] 0.52 ± 0.13 [0.56; 0.3–0.66] 0.36 ± 0.11 [0.39; 0.18–0.49]
*p = 0.05
#P = 0.005
  1. Mean ± standard deviation [median; minimum–maximum range]
  2. VOI volume of interest, HD Hausdorff distance, MDA mean distance to agreement, N/A not applicable
  3. *Combined (seg4) vs. reader 1 (seg1)
  4. #Combined (seg4) vs. reader 2 (seg2)