Fig. 4

Bubble plot of underestimated tumor volumes. The percentage underestimation of the true tumor volume as determined by histology is given for the two human readers (seg1, seg2), the gradient-based segmentation method (seg3), and the union of seg1–3 (seg4). The diameter of the colored bubbles is proportional to the true tumor volume, and the color reflects the patient ID across segmentations (see Table 1). Please note that the underestimated tumor volume for the patient with the longest time period between imaging and prostatectomy, harboring the only high-risk cancer in this cohort (patient ID 9), is well within the range of the remaining patients