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Table 4 Stability of gallium-68 conjugates at 37 °C in the presence of different metal cations at 10− 2 M concentrations (n = 3)

From: Labeling of DOTA-conjugated HPMA-based polymers with trivalent metallic radionuclides for molecular imaging

Conjugate Linker % DOTA % of intact 68Ga conjugate ± SD
Fe3+ Mg2+ Ca2+
31c (1) 1.6 94 ± 3 92 ± 1 92 ± 5
33 (3) 1.6 94 ± 9 69 ± 2 99 ± 2
34a (4) 0.6 88 ± 2 80 ± 3 70 ± 1
34b (4) 1.2 84 ± 2 86 ± 2 90 ± 1
35 (5) 3.5 74 ± 2 85 ± 1 83 ± 8