Table 4 Parameters pre-RDN in patients with a positive delta (i.e., increase in ¹²³I–mIBG uptake at 15 min) versus patients with a negative delta (i.e., decrease in ¹²³I–mIBG uptake at 15 min) after RDN

Increase (n = 14)

Decrease (n = 7)

p value

 Male n

10

5

0.701

 Age (years)

56.4 [48.6–63.3]

67.0 [60.5–67.6]

0.062

 BMI (kg/m²)

26.98 [24.52–28.96]

30.02 [27.4725–31.7451]

0.205

 Left ventricular hypertrophy, n

4

2

0.686

 CVD, n

5

5

0.140

 Type 2 diabetes mellitus, n

3

4

0.127

 Ethnicity (Caucasian), n

11

5

0.557

 Antihypertensives, n

4.6 ± 1.2

4.4 ± 1.6

0.590

 Office systolic BP (mmHg)

177.5 [162.5–187.3]

168.0 [153.0–179.0]

0.370

 Office diastolic BP

104.0 [92.0–116.5]

95.0 [76.0–102.0]

0.101

 ABPM daytime systolic BP

171.50[157.5–181.8]

159.00 [154.0–173.0]

0.433

 ABPM daytime diastolic BP

100.5 [93.5–112.5]

90.0 [81.0–101.0]

0.126

 ABPM night time systolic BP

153.0 [135.0–158.3]

139.0 [132.0–180.0]

0.550

 ABPM night time diastolic BP

86.5 [77.0–91.3]

77.0 [71.0–87.0]

0.145

 ABPM average systolic BP

163.5 [154.5–172.5]

151.0 [149.0–175.0]

0.411

 ABPM average diastolic BP

95.5 [88.0–105.0]

85.0 [80.0–96.0]

0.101

 Washout GM 15 min - 4 h

35.463 [25.68–47.36]

59.365 [38.73–62.39]

0.014

 GM uptake 15 min

2.9590 [2.3403–4.26]

5.4906 [3.03–5.69]

0.017

 GM uptake 4 h

1.84 [1.17–2.14]

1.53 [1.45–1.64]

0.456

 CT uptake 4 h

1.33 [0.84–2.07]

1.56 [1.26–1.87]

0.552

 eGFR (ml/min/1.73 m2)

63.6 [49.4–96.1]

53.3 [48.4–138.3]

0.765

 Serum creatinine (μmol/L)

91.0 [77.8–112.5]

98.0 [67.0–104.0]

0.852

 Sodium urine (mmol/24 h)

150.80 [104.40–200.55]

170.1 [71.5–275.4]

1.000

 Plasma renin activity (μg/A1/L/h)

1.65 [0.78–1.95]

2.20 [1.00–4.60]

0.370

 Epinephrine supine, plasma (nmol/L)

0.12 [0.05–0.15]

0.17 [0.05–0.50]

0.554

 Norepinephrine supine, plasma (nmol/L)

2.72 [1.22–3.96]

2.22 [1.71–2.89]

0.837

 Epinephrine urine (nmol/24 h)

26.00 [10.75–36.25]

28.00 [20.75–32.25]

0.903