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Table 4 Parameters pre-RDN in patients with a positive delta (i.e., increase in 123I–mIBG uptake at 15 min) versus patients with a negative delta (i.e., decrease in 123I–mIBG uptake at 15 min) after RDN

From: Renal sympathetic nerve activity after catheter-based renal denervation

Baseline parameters (pre-RDN)  
  Increase (n = 14) Decrease (n = 7) p value
Demography
 Male n 10 5 0.701
 Age (years) 56.4 [48.6–63.3] 67.0 [60.5–67.6] 0.062
 BMI (kg/m2) 26.98 [24.52–28.96] 30.02 [27.4725–31.7451] 0.205
 Left ventricular hypertrophy, n 4 2 0.686
 CVD, n 5 5 0.140
 Type 2 diabetes mellitus, n 3 4 0.127
 Ethnicity (Caucasian), n 11 5 0.557
Blood pressure
 Antihypertensives, n 4.6 ± 1.2 4.4 ± 1.6 0.590
 Office systolic BP (mmHg) 177.5 [162.5–187.3] 168.0 [153.0–179.0] 0.370
 Office diastolic BP 104.0 [92.0–116.5] 95.0 [76.0–102.0] 0.101
 ABPM daytime systolic BP 171.50[157.5–181.8] 159.00 [154.0–173.0] 0.433
 ABPM daytime diastolic BP 100.5 [93.5–112.5] 90.0 [81.0–101.0] 0.126
 ABPM night time systolic BP 153.0 [135.0–158.3] 139.0 [132.0–180.0] 0.550
 ABPM night time diastolic BP 86.5 [77.0–91.3] 77.0 [71.0–87.0] 0.145
 ABPM average systolic BP 163.5 [154.5–172.5] 151.0 [149.0–175.0] 0.411
 ABPM average diastolic BP 95.5 [88.0–105.0] 85.0 [80.0–96.0] 0.101
123 I–mIBG parameters
 Washout GM 15 min - 4 h 35.463 [25.68–47.36] 59.365 [38.73–62.39] 0.014
 GM uptake 15 min 2.9590 [2.3403–4.26] 5.4906 [3.03–5.69] 0.017
 GM uptake 4 h 1.84 [1.17–2.14] 1.53 [1.45–1.64] 0.456
 CT uptake 4 h 1.33 [0.84–2.07] 1.56 [1.26–1.87] 0.552
Kidney function
 eGFR (ml/min/1.73 m2) 63.6 [49.4–96.1] 53.3 [48.4–138.3] 0.765
 Serum creatinine (μmol/L) 91.0 [77.8–112.5] 98.0 [67.0–104.0] 0.852
 Sodium urine (mmol/24 h) 150.80 [104.40–200.55] 170.1 [71.5–275.4] 1.000
(Neuro) endocrinology
 Plasma renin activity (μg/A1/L/h) 1.65 [0.78–1.95] 2.20 [1.00–4.60] 0.370
 Epinephrine supine, plasma (nmol/L) 0.12 [0.05–0.15] 0.17 [0.05–0.50] 0.554
 Norepinephrine supine, plasma (nmol/L) 2.72 [1.22–3.96] 2.22 [1.71–2.89] 0.837
 Epinephrine urine (nmol/24 h) 26.00 [10.75–36.25] 28.00 [20.75–32.25] 0.903
  1. Data are presented as medians with interquartile ranges (IQR 25–75%). GM = geometric mean images, with muscle as background, SPECT = single photon emission computed tomography, RDN = Renal denervation GM = geometric mean