Table 2 Tumour uptake of 89Zr-RG7356 and RG7356 at 96 h p.i.
Patient | Dose cohort (mg) | Visual assessment | Localisation | SUVpeak | AUC (mg h/mL) | Tumour-to-blood AUC ratio |
|---|---|---|---|---|---|---|
1 | 1 | − | − | − | − | − |
2 | 100 | − | − | − | − | − |
3 | 100 | * | − | − | − | − |
4 | 100 | − | − | − | − | − |
5 | 200 | − | − | − | − | − |
6 | 200 | − | − | − | − | − |
7 | 450 | + | Brain L | 1.8 | 0.35 | 0.09 |
Lung R | 8.4 | 2.06 | 0.55 | |||
8 | 450 | + | Skull L | 3.3 | 1.41 | 0.43 |
Upper neck L | 3.5 | 1.62 | 0.49 | |||
Lower neck L | 2.8 | 1.43 | 0.43 | |||
Supraclavicular R | 3.1 | 1.67 | 0.50 | |||
Mediastinal | 4.8 | 2.37 | 0.72 | |||
Lung L | 2.2 | 1.29 | 0.39 | |||
Lung R1 | 2.1 | 1.06 | 0.32 | |||
Lung R2 | 4.3 | 1.75 | 0.53 | |||
9 | 450 | + | Lung L | 1.8 | 0.89 | 0.32 |
Lung R | 2.2 | 0.99 | 0.36 | |||
Rectum | 5.6 | 1.75 | 0.64 | |||
10 | 450 | + | Lung L | 4.6 | 1.47 | 0.56 |
Lung R | 3.9 | 1.41 | 0.53 | |||
11 | 450 | + | Mastoid L | 4.5 | 1.81 | 0.42 |
12 | 675 | + | Sigmoid L | 4.9 | 2.55 | 0.59 |
13 | 675 | + | Pelvic R | 6.5 | 3.83 | 0.73 |
Sacrum | 8.1 | 3.29 | 0.63 |