Fig. 1From: Assessment of target-mediated uptake with immuno-PET: analysis of a phase I clinical trial with an anti-CD44 antibodyImmuno-PET signal components in a phase I dose escalation study. The tissue-to-blood ratio is shown as a function of administered antibody dose. For example, target antigen-mediated uptake is dose-dependent, while blood volume fraction, catabolism or elimination are dose-independent accumulation mechanismsBack to article page