Prognostic value of simultaneous 18F-FDG PET/MRI using a combination of metabolo-volumetric parameters and apparent diffusion coefficient in treated head and neck cancer

EJNMMI Research

Table 5 Multivariate analysis with significant clinicopathologic and ¹⁸F-PET/MRI parameters

Parameters	Model with MTV		Model with MTV/ADCmean		Model with TLG/ADCmean
Parameters	Hazards ratio (95% CI)	P value	Hazards ratio (95% CI)	P value	Hazards ratio (95% CI)	P value
Lymphatic invasion (yes vs. no)	2.66 (1.13–6.27)	0.026*	2.66 (1.13–6.27)	0.026*	2.57 (1.02–6.45)	0.044*
Perineural invasion (yes vs. no)		NS				NS
MTV (> 11.08 vs. ≤ 11.08)	3.06 (1.31–7.13)	0.010*		N/A		N/A
(MTV/ADCmean) × 1000 (> 10.8 vs. ≤ 10.8)		N/A	3.12 (1.31–7.48)	0.011*		N/A
(TLG/ADCmean) × 1000 (> 108.9 vs. ≤ 108.9)		N/A		N/A	4.33 (1.72–10.87)	0.002*