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Table 2 Mean organ absorbed radiation doses and effective doses normalized to the unit-injected activity (mean ± SD) of [64Cu]CuCl2 in healthy subjects

From: Biodistribution and radiation dosimetry of [64Cu]copper dichloride: first-in-human study in healthy volunteers

Organ

Adult Male

Absorbed dose

(μGy/MBq)

Adult Female

Absorbed dose

(μGy/MBq)

Adrenals

30.0 ± 0.9

37.8 ± 0.7

Brain

4.2 ± 0.1

5.4 ± 0.5

Breasts

16.0 ± 1.3

20.3 ± 1.9

Gallbladder Wall

44.3 ± 2.9

54.1 ± 2.6

LLI Wall

153 ± 40

161 ± 26

Small Intestine

55.0 ± 11.0

62.6 ± 6.4

Stomach Wall

22.7 ± 1.3

29.1 ± 1.3

ULI Wall

131 ± 31

144 ± 23

Heart Wall

22.9 ± 0.6

29.8 ± 1.4

Kidneys

69.7 ± 15.7

90.0 ± 21.2

Liver

310 ± 67

421 ± 56

Lungs

20.8 ± 0.7

27.2 ± 1.4

Muscle

18.0 ± 1.6

22.5 ± 1.9

Ovaries*

24.3 ± 3.8

30.0 ± 0.8

Pancreas

83.4 ± 9.1

105 ± 14

Red Marrow

16.7 ± 1.3

19.9 ± 1.2

Osteogenic cells

32.9 ± 3.8

43.4 ± 5.0

Skin

14.6 ± 1.6

18.3 ± 1.9

Spleen

19.6 ± 1.5

25.3 ± 4.7

Testes

15.5 ± 2.2

Thymus

17.3 ± 1.6

22.0 ± 2.3

Thyroid

15.5 ± 2.0

18.8 ± 2.5

Urinary Bladder Wall

18.8 ± 2.6

21.4 ± 2.0

Uterus*

21.2 ± 3.0

26.3 ± 1.6

Total Body

26.9 ± 0.1

34.1 ± 0.2

Effective Dose (μSv/MBq)

51.2 ± 3.0

61.8 ± 5.2

  1. *Dosimetric calculations for men