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EJNMMI Research

Table 3 PET/CT-derived distribution of 18F-TFB in healthy participants

From: Safety, pharmacokinetics, metabolism and radiation dosimetry of 18F-tetrafluoroborate (18F-TFB) in healthy human subjects

Organ

2 h post-injection (SUV)

3.5 h post-injection (SUV)

Males

Females

Males

Females

Bone

0.80 ± 0.33

0.74 ± 0.20

1.4 ± 0.5*

1.3 ± 0.9*

Brain

0.39 ± 0.14

0.42 ± 0.15

0.74 ± 0.26*

0.61 ± 0.34*

Breast

–

2.8 ± 0.4

–

3.9 ± 1.4

Gallbladder

2.7 ± 1.5

3.7 ± 1.0

4.2 ± 1.7*

5.0 ± 1.6*

Intestines

2.9 ± 1.0

5.0 ± 2.7

4.4 ± 1.0

6.0 ± 3.1

Kidney

7.0 ± 2.5

5.6 ± 0.7

11 ± 3*

6.3 ± 2.4*

Liver

2.3 ± 1.0

2.7 ± 0.5

3.6 ± 1.2*

3.5 ± 1.6*

Lung

1.0 ± 0.4

1.2 ± 0.4

1.7 ± 0.6*

1.5 ± 0.8*

Muscle

0.71 ± 0.31

0.65 ± 0.35

0.96 ± 0.31*

0.78 ± 0.54*

Myocardium

3.2 ± 0.9

2.8 ± 0.5

5.0 ± 0.9*

3.8 ± 1.8*

Pancreas

3.4 ± 0.7

3.1 ± 1.7

6.2 ± 2.1

3.0 ± 1.2

Parotid

11 ± 9

20 ± 11

16 ± 13*

25 ± 15*

Spleen

4.1 ± 1.2

4.3 ± 1.0

6.3 ± 1.1*

5.5 ± 2.8*

Stomach

33 ± 15

72 ± 10

70 ± 32

51 ± 18

Thyroid

55 ± 31

50 ± 11

82 ± 42*

58 ± 12*

  1. Values are mean ± SD (n = 4)
  2. *p < 0.05 versus 2 h
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