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Table 2 Metabolite analysis of 18F-TFB in plasma and urine of healthy participants

From: Safety, pharmacokinetics, metabolism and radiation dosimetry of 18F-tetrafluoroborate (18F-TFB) in healthy human subjects

  40 mina 145 mina 235 mina Accumulative
Males Females Males Females Males Females Males Females
Whole blood (SUV) 3.0 ± 0.2 3.1 ± 0.9 2.1 ± 0.2 1.7 ± 0.4 1.7 ± 0.2 1.4 ± 0.4
Plasma (SUV) 3.8 ± 0.2 3.8 ± 1.0 2.8 ± 0.3 2.1 ± 0.5 2.0 ± 0.1 1.7 ± 0.5
Urine (%dose) 15 ± 2b 16 ± 3 13 ± 3 18 ± 3 10 ± 2b 12 ± 2 40 ± 5b 46 ± 7
%Intact 18F-TFB Plasma 97 ± 2 97 ± 3c d d d d
Urine 96 ± 2 98 ± 1 97 ± 2 98 ± 1 98 ± 1 97 ± 2
  1. Values are mean ± SD (n = 4)
  2. aTime points are shown for blood samples; urine samples were collected ~ 10 min later
  3. bNo urine in third collection of one male subject
  4. cOne plasma sample was not used because precipitate was observed in the HPLC analysis
  5. dMetabolite data were not obtained in second and third plasma samples analysis because the low radioactivity levels were below detection limit