Oxygen-15 labeled CO2, O2, and CO PET in small animals: evaluation using a 3D-mode microPET scanner and impact of reconstruction algorithms

EJNMMI Research

Table 2 CBF, OEF, CMRO₂, and CBV of each brain region reconstructed using FBP (*P < 0.05, **P < 0.01 versus cerebellum)

	CBF (mL/100 mL/min)	OEF (%)	CMRO₂ (mL/100 mL/min)	CBV (mL/100 mL)
Frontal cortex	33.9 ± 8.7^*	70.7 ± 9.6^*	4.44 ± 0.50	5.30 ± 0.57
Somatosensory cortex	38.4 ± 9.2^*	72.2 ± 8.2^**	5.21 ± 0.35	3.60 ± 0.43^**
Visual cortex	34.2 ± 8.5^**	66.6 ± 7.3^**	4.21 ± 0.45^**	5.56 ± 0.77
Striatum	62.1 ± 19.6^**	67.5 ± 8.1^**	8.30 ± 0.66^**	4.17 ± 0.29^**
Thalamus	68.5 ± 22.7^**	67.1 ± 8.1^**	9.17 ± 0.72^**	3.97 ± 0.36^**
Pons	48.2 ± 14.9	54.1 ± 6.3	5.19 ± 0.30	5.31 ± 0.53
Cerebellum	47.5 ± 14.5	56.6 ± 6.3	5.07 ± 0.63	5.63 ± 0.44
Hippocampus	57.4 ± 17.3^**	67.1 ± 7.5^**	7.55 ± 0.57^**	5.14 ± 0.49
Midbrain	69.3 ± 22.7^**	61.4 ± 6.0^*	8.63 ± 0.67^**	4.40 ± 0.25^**
Whole brain	46.6 ± 12.5	63.7 ± 7.2^**	5.72 ± 0.34^*	5.66 ± 0.34