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Table 3 Sequential testing on equality of areas under ROC curves [17]

From: Group-sequential analysis may allow for early trial termination: illustration by an intra-observer repeatability study

Number of interim analyses P value (sample size) and respective significance level at analysis time point
Interim analysis 1 Interim analysis 2 Interim analysis 3 Final analysis
0 0.0189 (N = 100) α 1 = 0.05
1 0.1557 (N = 50) α 0.5 = 0.025 0.0189 (N = 100) α 1 = 0.05
2 0.0669 (N = 33) α 0.33 = 0.0167 0.0577 (N = 67) α 0.67 = 0.0333 0.0189 (N = 100) α 1 = 0.05
3 0.0174 (N = 25) α 0.25 = 0.0125 0.1557 (N = 50) α 0.5 = 0.025 0.0395 (N = 75) α 0.75 = 0.0375 0.0189 (N = 100) α 1 = 0.05