EJNMMI Research

Table 4 Tumour and muscle imaging parameters representing blood perfusion (F) and hypoxia (K _a) from fitting 45 min [¹⁸F]FMISO PET readings to Casciari model at baseline and after 8–10 fractions of chemoradiotherapy (CRT). Response is as defined in Table 1

From: [¹⁸F]Fluoromisonidazole PET in rectal cancer

		Tumour						Muscle
Patient	Clinical	Baseline		After 8–10# CRT		% Changes		Baseline		After 8–10# CRT		% changes
Number	Response	F	K_a	F	K_a	F	K_a	F	K_a	F	K_a	F	K_a
P1	Poor	0.588	1.380	0.294	1.188	−50	−14	0.144	0.018	0.570	0.864	296	4700
P2	Good	1.428	1.578	2.472	0.702	73	−56	0.102	0.042	0.672	1.434	559	3314
P3	Poor	3.198	0.912	2.484	0.696	−22	−24	0.120	0.018	0.600	0.360	400	1900
P4	Poor	4.410	0.630	3.132	0.702	−29	11	0.126	0.024	0.600	0.360	376	1400
P5	Good	6.702	0.924	4.380	0.720	−35	−22	0.138	0.006	0.600	0.360	335	5900
P6	Poor	6.702	0.924	–	–	–	–	0.600	0.444	–	–	–	–
P7	Good	3.942	0.924	4.656	0.618	18	−33	0.174	0	0.054	1.116	−69	n.d.
P8	Poor	4.368	0.870	0.750	0.312	−83	−64	0.078	4.806	0.348	2.058	346	−57
P9	Poor	4.248	0.714	0.756	0.096	−82	−87	0.084	0.036	0.480	1.056	471	2833
P10	Good	–	–	–	–	–	–	–	–	–	–	–	–
P11	Good	2.526	0.762	6.192	0.720	145	−6	0.114	0.006	0.600	0.366	426	6000
Median		4.100	0.920	2.480	0.700	−28.980	−23.680	0.120	0.020	0.600	0.860	376.190	3073.810
IQR		1.710	0.140	3.620	0.100	68.110	41.600	0.040	0.030	0.120	0.760	91.530	3225.000

[ ¹⁸ F]FMISO [¹⁸F]fluoromisonidazole, % percentage, n.d. not defined, IQR interquartile range. PET positron emission tomography, min minute

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