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EJNMMI Research
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Table 4 Tumour and muscle imaging parameters representing blood perfusion (F) and hypoxia (K a ) from fitting 45 min [18F]FMISO PET readings to Casciari model at baseline and after 8–10 fractions of chemoradiotherapy (CRT). Response is as defined in Table 1

From: [18F]Fluoromisonidazole PET in rectal cancer

   Tumour Muscle
Patient Clinical Baseline After 8–10# CRT % Changes Baseline After 8–10# CRT % changes
Number Response F Ka F Ka F Ka F Ka F Ka F Ka
P1 Poor 0.588 1.380 0.294 1.188 −50 −14 0.144 0.018 0.570 0.864 296 4700
P2 Good 1.428 1.578 2.472 0.702 73 −56 0.102 0.042 0.672 1.434 559 3314
P3 Poor 3.198 0.912 2.484 0.696 −22 −24 0.120 0.018 0.600 0.360 400 1900
P4 Poor 4.410 0.630 3.132 0.702 −29 11 0.126 0.024 0.600 0.360 376 1400
P5 Good 6.702 0.924 4.380 0.720 −35 −22 0.138 0.006 0.600 0.360 335 5900
P6 Poor 6.702 0.924 – – – – 0.600 0.444 – – – –
P7 Good 3.942 0.924 4.656 0.618 18 −33 0.174 0 0.054 1.116 −69 n.d.
P8 Poor 4.368 0.870 0.750 0.312 −83 −64 0.078 4.806 0.348 2.058 346 −57
P9 Poor 4.248 0.714 0.756 0.096 −82 −87 0.084 0.036 0.480 1.056 471 2833
P10 Good – – – – – – – – – – – –
P11 Good 2.526 0.762 6.192 0.720 145 −6 0.114 0.006 0.600 0.366 426 6000
Median   4.100 0.920 2.480 0.700 −28.980 −23.680 0.120 0.020 0.600 0.860 376.190 3073.810
IQR   1.710 0.140 3.620 0.100 68.110 41.600 0.040 0.030 0.120 0.760 91.530 3225.000
  1. [ 18 F]FMISO [18F]fluoromisonidazole, % percentage, n.d. not defined, IQR interquartile range. PET positron emission tomography, min minute
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