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Table 3 Tumour:Blood (T:B) SUVmax ratio and hypoxic volume at baseline and after 8–10 fractions of CRT from [18F]FMISO PET scans at 4 h

From: [18F]Fluoromisonidazole PET in rectal cancer

  Baseline After 8–10# CRT % Change
Patient pTRG Stage Clinical Tumour Blood T:B Tumour Tumour % of Tumour Blood T:B Tumour Tumour % of Tumour Blood T:B Tumour Tumour % of
Number AJCC   Response SUV SUV SUV hypoxic ROI tumour SUV SUV SUV hypoxic ROI tumour SUV SUV SUV hypoxic ROI tumour
     max max max volume volume volume max max max volume volume volume max max max volume volume volume
        cm3 cm3 i.e. hypoxic     cm3 cm3 i.e. hypoxic       i.e. hypoxic
P1 1 ypT3N2 Poor 2.09 1.32 1.58 0.39 80.41 0.48 1.79 1.13 1.58 1.27 88.60 1.43 −14.35 −14.65 0.34 225.99 10.19 195.85
P2 1 ypT3N1 Good 5.19 1.45 3.57 8.41 23.20 36.25 4.97 1.56 3.18 3.99 26.85 14.85 −4.31 7.44 −10.94 −52.62 15.70 −59.05
P3 3 ypT3N0 Poor 3.39 1.76 1.93 5.31 179.77 2.95 2.24 1.44 1.56 0.59 86.53 0.68 −33.78 −18.14 −19.11 −88.94 −51.87 −77.02
P4 2 ypT3N0 Poor 4.16 1.57 2.66 6.58 30.66 21.45 2.70 1.56 1.73 0.76 13.35 5.68 −35.10 −0.11 −35.02 −88.48 −56.46 −73.53
P5 NR N/A Good 4.98 1.31 3.79 14.38 62.59 22.97 1.78 1.62 1.10 0.00 55.79 0.00 −64.17 23.60 −71.01 −100.00 −10.86 −100.00
P6 NR N/A Poor 3.38 1.50 2.26 6.06 18.80 32.25 - - - - - - - - - - - -
P7 NR N/A Good 3.52 1.06 3.33 1.17 4.16 28.24 2.44 1.14 2.14 0.51 0.93 55.26 −30.54 7.81 −35.58 −56.25 −77.65 95.72
P8 2 ypT3N2 Poor 5.31 1.19 4.45 10.66 28.43 37.49 2.49 1.46 1.71 1.91 28.61 6.68 −53.14 22.10 −61.62 −82.08 0.60 −82.19
P9 2 ypT3N1 Poor 3.04 1.35 2.25 2.08 15.06 13.80 1.82 1.14 1.60 1.30 13.96 9.28 −39.97 −15.35 −29.09 −37.64 −7.31 −32.73
P10 0 ypT0N1 Good - -
P11 2 ypT3N0 Good* 1.94 1.22 1.58 2.15 10.98 19.61 2.40 1.49 1.61 0.15 5.23 2.80 23.87 21.73 1.76 0.00 −52.34 0.00
Median     3.45 1.34 2.46 5.68 25.82 22.21 2.40 1.46 1.61 0.76 26.85 5.68 −33.78 7.44 −29.09 −56.25 −10.86 −59.05
IQR     1.65 0.24 1.50 5.86 38.61 16.00 0.67 0.42 0.14 0.78 42.44 7.85 25.62 36.37 24.64 50.83 52.94 77.02
  1. Response is as defined in Table 1. Blood was used from blood sample activity
  2. [ 18 F]FMISO [18F]fluoromisonidazole, PET positron emission tomography, h hour, SUV standardised uptake value, T:B tumour to blood ratio, max maximum, cm 3cubic centimetre, % percentage, CRT chemoradiotherapy, IQR interquartile range, i.e. that is, ROI region of interest, NR No resection, N/A not applicable,  TRG tumour regression grade, AJCC American Joint Committee on Cancer, * Delayed surgery due to initial good response, clinical outcome used