Motor impairment and compensation in a hemiparkinsonian rat model: correlation between dopamine depletion severity, cerebral metabolism and gait patterns

Kordys, Elena; Apetz, Nadine; Schneider, Katharina; Duncan, Eilidh; Büschbell, Beatriz; Rohleder, Cathrin; Sué, Michael; Drzezga, Alexander; Neumaier, Bernd; Timmermann, Lars; Endepols, Heike

doi:10.1186/s13550-017-0317-9

EJNMMI Research

Table 2 Correlation between gait parameters and metabolic activity in selected brain areas, measured with [¹⁸F]FDG (n = 13)

From: Motor impairment and compensation in a hemiparkinsonian rat model: correlation between dopamine depletion severity, cerebral metabolism and gait patterns

		Contralesional front paw	Contralesional hind paw	Ipsilesional front paw	Ipsilesional hind paw
RFA, ipsilesional
Swing speed	cm/s	R = 0.67 p = 0.0119*	R = 0.62 p = 0.0239*	R = 0.62 p = 0.0224*	R = 0.60 p = 0.0300*
Swing duration	s	R = −0.59 p = 0.0355*	R = −0.47 p = 0.1065	R = −0.41 p = 0.1660	R = −0.38 p = 0.1966
Stance duration	s	R = −0.54 p = 0.0577	R = −0.63 p = 0.0209*	R = −0.64 p = 0.0194*	R = −0.64 p = 0.0187*
Stride length	cm	R = 0.59 p = 0.0343*	R = 0.64 p = 0.0190*	R = 0.55 p = 0.0496*	R = 0.61 p = 0.0272*
Print area	cm²	R = −0.16 p = 0.6118	R = −0.16 p = 0.6051	R = −0.31 p = 0.3030	R = −0.69 p = 0.0087**
Body speed	cm/s	R = 0.64 p = 0.0176*	R = 0.68 p = 0.0110*	R = 0.66 p = 0.0141*	R = 0.67 p = 0.0120*
lpTh, ipsilesional
Swing speed	cm/s	R = 0.69 p = 0.0084**	R = 0.71 p = 0.0070**	R = 0.67 p = 0.0115*	R = 0.66 p = 0.0139*
Stance duration	s	R = −0.63 p = 0.0208*	R = −0.61 p = 0.0270*	R = −0.65 p = 0.0155*	R = −0.65 p = 0.0155*
Stride length	cm	R = 0.70 p = 0.0082**	R = 0.74 p = 0.0041**	R = 0.69 p = 0.0087**	R = 0.75 p = 0.0030**
Body speed	cm/s	R = 0.69 p = 0.0094**	R = 0.71 p = 0.0071**	R = 0.71 p = 0.0062**	R = 0.71 p = 0.0066**
cStr, contralesional
Swing speed	cm/s	R = −0.70 p = 0.0072**	R = −0.79 p = 0.0013**	R = −0.67 p = 0.0117*	R = −0.71 p = 0.0065**
Swing duration	s	R = 0.53 p = 0.0613	R = 0.71 p = 0.0067**	R = 0.35 p = 0.2454	R = 0.49 p = 0.0888
Stance duration	s	R = 0.68 p = 0.0100*	R = 0.64 p = 0.0173*	R = 0.73 p = 0.0047**	R = 0.71 p = 0.0071**
Stride length	cm	R = −0.74 p = 0.0038**	R = −0.76 p = 0.0023**	R = −0.74 p = 0.0042**	R = −0.82 p = 0.0006**
Print area	cm²	R = 0.05 p = 0.8757	R = 0.17 p = 0.5808	R = 0.54 p = 0.0559	R = 0.66 p = 0.0146*
Body speed	cm/s	R = −0.72 p = 0.0059**	R = −0.76 p = 0.0028**	R = −0.77 p = 0.0023**	R = −0.75 p = 0.0033**
CerV, contralesional
Stance duration	s	R = 0.59 p = 0.0320*	R = 0.44 p = 0.1360	R = 0.59 p = 0.0354*	R = 0.50 p = 0.0833
Stride length	cm	R = −0.45 p = 0.1187	R = −0.55 p = 0.0529	R = −0.44 p = 0.1310	R = −0.58 p = 0.0388*
MLR, contralesional
Swing speed	cm/s	R = −0.63 p = 0.0223*	R = −0.64 p = 0.0196*	R = −0.56 p = 0.045*	R = −0.51 p = 0.0724
Swing duration	s	R = 0.49 p = 0.0884	R = 0.63 p = 0.0188*	R = 0.29 p = 0.3419	R = 0.24 p = 0.4254
Stance duration	s	R = 0.66 p = 0.0145*	R = 0.57 p = 0.0436*	R = 0.66 p = 0.0137*	R = 0.66 p = 0.0142*
Stride length	cm	R = −0.61 p = 0.0263*	R = −0.70 p = 0.0078**	R = −0.61 p = 0.0261*	R = −0.70 p = 0.0077**
Print area	cm²	R = 0.20 p = 0.5064	R = 0.16 p = 0.6111	R = 0.35 p = 0.2478	R = 0.60 p = 0.0315*
Body speed	cm/s	R = −0.59 p = 0.0346*	R = −0.62 p = 0.0248*	R = −0.62 p = 0.0242*	R = −0.62 p = 0.0234*

Positive correlations ipsilateral: low metabolism is associated with a low behavioural value. Positive correlations contralateral: high metabolism is associated with a high behavioural value. Negative correlations ipsilateral: low metabolism is associated with a high behavioural value. Negative correlations contralateral: high metabolism is associated with a low behavioural value. *p < 0.05; **p < 0.01
Abbreviations: CerV cerebellum, lobulus V, lpTh lateral posterior thalamic nucleus, MLR midbrain locomotor region, RFA rostral forelimb area

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