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EJNMMI Research

Table 1 Biodistribution of 4-[18F]FEBZA in mice bearing tumor xenografts

From: Selective targeting of melanoma using N-(2-diethylaminoethyl) 4-[18F]fluoroethoxy benzamide (4-[18F]FEBZA): a novel PET imaging probe

 

%IA/g tissue (mean ± SD)

Organ

B16F1 tumor

HT-29 tumor

C-32 tumor

 

1 h

2 h

1 h

2 h

1 h

2 h

(n = 6)

(n = 5)

(n = 3)

(n = 3)

(n = 3)

(n = 3)

Liver

3.25 ± 0.34

2.28 ± 0.49

4.84 ± 0.95

2.50 ± 0.29

3.11 ± 0.49

1.99 ± 0.12

Spleen

2.24 ± 0.36

1.58 ± 0.18

2.11 ± 0.25

1.51 ± 0.12

1.96 ± 0.38

1.22 ± 0.08

Lung

2.12 ± 0.17

1.49 ± 0.49

2.19 ± 0.33

1.63 ± 0.16

1.94 ± 0.67

1.33 ± 0.35

Heart

2.82 ± 0.25

2.12 ± 0.58

2.52 ± 0.12

2.19 ± 0.37

2.52 ± 0.15

1.75 ± 0.35

Kidneys

3.10 ± 0.28

2.20 ± 0.38

2.91 ± 0.24

2.08 ± 0.29

2.85 ± 0.37

1.84 ± 0.12

Bone

3.78 ± 0.45

5.45 ± 0.98

3.83 ± 0.39

5.71 ± 1.11

3.47 ± 0.78

5.09 ± 0.72

Sm. Intestine

2.49 ± 0.25

1.60 ± 0.31

1.98 ± 0.62

1.42 ± 0.10

2.23 ± 0.21

1.33 ± 0.06

Pancreas

2.48 ± 0.35

1.73 ± 0.14

2.41 ± 0.26

1.56 ± 0.18

2.49 ± 0.42

1.40 ± 0.10

Muscles

1.51 ± 0.21

1.14 ± 0.21

1.61 ± 0.28

1.40 ± 0.24

2.35 ± 1.06

1.05 ± 0.14

Brain

2.55 ± 0.61

2.25 ± 0.50

1.68 ± 0.18

1.52 ± 0.28

1.87 ± 0.21

1.36 ± 0.17

Adrenals

1.10 ± 0.36

0.88 ± 0.06

1.07 ± 0.08

0.91 ± 0.19

1.26 ± 0.39

0.77 ± 0.18

Blood

3.06 ± 0.52

2.51 ± 0.93

2.80 ± 0.26

2.29 ± 0.23

3.22 ± 0.64

2.40 ± 0.30

Tumor

8.66 ± 1.02

7.47 ± 1.34

3.68 ± 0.47

3.07 ± 0.36

3.91 ± 0.23

2.53 ± 0.19

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