Table 1 [11C]PBR28 experimental results
From: Microglial depletion and activation: A [11C]PBR28 PET study in nonhuman primates
Study | Measurement | Caudate | Putamen | Hippocampus | Cingulate cortex | Frontal cortex | Occipital cortex | Temporal cortex | Cerebellum | Thalamus | f P (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|
Baseline Pre-PLX | V T (mL/cm3) | 33.2 | 29.1 | 30.0 | 33.6 | 30.7 | 24.5 | 32.3 | 23.3 | 26.9 | 7.8 |
Immediate Post-PLX | V T (mL/cm3) | 16.6 | 15.1 | 17.3 | 16.9 | 16.1 | 13.7 | 18.3 | 12.8 | 14.6 | 5.7 |
% Change from BL | −50% | −48% | −42% | −50% | −48% | −44% | −43% | −45% | −46% | −27% | |
12-day Post-PLX | V T (mL/cm3) | 26.4 | 26.8 | 28.4 | 31.7 | 29.3 | 23.4 | 30.0 | 22.8 | 24.8 | 7.9 |
% Change from BL | −20% | −8% | −5% | −6% | −4% | −4% | −7% | −2% | −8% | 1% | |
Baseline Pre-LPS | V T (mL/cm3) | 52.4 | 40.7 | 49.4 | 45.4 | 48.9 | 48.4 | 47.9 | 50.9 | 45.5 | 8.2 |
Baseline Post-LPS | V T (mL/cm3) | 71.4 | 58.4 | 74.3 | 67.1 | 64.3 | 59.0 | 66.9 | 68.5 | 65.7 | 11.3 |
% Change from BL | 36% | 44% | 50% | 48% | 32% | 22% | 40% | 35% | 44% | 38% | |
2-week Post-LPS | V T (mL/cm3) | 45.4 | 35.7 | 45.5 | 39.0 | 42.9 | 41.5 | 44.4 | 47.3 | 39.8 | 8.0 |
% Change from BL | −13% | −12% | −8% | −14% | −12% | −14% | −7% | −7% | −13% | −2% |