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Table 1 [11C]PBR28 experimental results

From: Microglial depletion and activation: A [11C]PBR28 PET study in nonhuman primates

Study Measurement Caudate Putamen Hippocampus Cingulate cortex Frontal cortex Occipital cortex Temporal cortex Cerebellum Thalamus f P (%)
Baseline Pre-PLX V T (mL/cm3) 33.2 29.1 30.0 33.6 30.7 24.5 32.3 23.3 26.9 7.8
Immediate Post-PLX V T (mL/cm3) 16.6 15.1 17.3 16.9 16.1 13.7 18.3 12.8 14.6 5.7
% Change from BL −50% −48% −42% −50% −48% −44% −43% −45% −46% −27%
12-day Post-PLX V T (mL/cm3) 26.4 26.8 28.4 31.7 29.3 23.4 30.0 22.8 24.8 7.9
% Change from BL −20% −8% −5% −6% −4% −4% −7% −2% −8% 1%
Baseline Pre-LPS V T (mL/cm3) 52.4 40.7 49.4 45.4 48.9 48.4 47.9 50.9 45.5 8.2
Baseline Post-LPS V T (mL/cm3) 71.4 58.4 74.3 67.1 64.3 59.0 66.9 68.5 65.7 11.3
% Change from BL 36% 44% 50% 48% 32% 22% 40% 35% 44% 38%
2-week Post-LPS V T (mL/cm3) 45.4 35.7 45.5 39.0 42.9 41.5 44.4 47.3 39.8 8.0
% Change from BL −13% −12% −8% −14% −12% −14% −7% −7% −13% −2%