Assessment of simplified ratio-based approaches for quantification of PET [11C]PBR28 data

EJNMMI Research

Table 1 Mean values, variability and test-retest metrics for V_T, SUV, SUVR and DVR using the frontal cortex as the target region and the cerebellum (CBL) or whole brain (WB) as the denominator region for the ratio-based outcomes

Measure	Genotype	Denominator	Mean	COV	ICC	VAR	SEM
V_T-2TCM	HAB	–	3.9	42	0.89	21	14
V_T-2TCM	MAB	–	2.2	46	0.93	17	12
V_T-2TCM	All	CBL	0.98	7.1	0.54	4.7	4.9
V_T-2TCM	HAB	CBL	0.97	8.1	0.87	3.4	2.9
V_T-2TCM	MAB	CBL	0.99	6.6	0.17	5.9	6
V_T-2TCM	All	WB	1	3.6	0.52	3	2.5
V_T-2TCM	HAB	WB	1.1	3	0.33	3.1	2.4
V_T-2TCM	MAB	WB	1	3.7	0.55	2.9	2.5
SUV₄₀–_60 min	HAB	–	1.1	22	0.76	13	11
SUV₄₀–_60 min	MAB	–	0.8	31	0.91	13	9.1
SUV₄₀–_60 min	All	CBL	0.95	6.2	0.63	4.4	3.8
SUV₄₀–_60 min	HAB	CBL	0.94	7.5	0.85	3.2	2.9
SUV₄₀–_60 min	MAB	CBL	0.95	5.2	0.32	5.4	4.3
SUV₄₀–_60 min	All	WB	1	3.9	0.89	1.5	1.3
SUV₄₀–_60 min	HAB	WB	1	1.9	0.6	1.3	1.2
SUV₄₀–_60 min	MAB	WB	1	4	0.89	1.6	1.3

HAB high-affinity binders, MAB mixed-affinity binders, CBL cerebellum, WB whole brain, COV coefficient of variance (%), ICC intraclass correlation coefficient, VAR absolute percentage variability (%), SEM standard error of measurement (%)