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Table 1 Mean values, variability and test-retest metrics for VT, SUV, SUVR and DVR using the frontal cortex as the target region and the cerebellum (CBL) or whole brain (WB) as the denominator region for the ratio-based outcomes

From: Assessment of simplified ratio-based approaches for quantification of PET [11C]PBR28 data

Measure Genotype Denominator Mean COV ICC VAR SEM
VT-2TCM HAB 3.9 42 0.89 21 14
VT-2TCM MAB 2.2 46 0.93 17 12
VT-2TCM All CBL 0.98 7.1 0.54 4.7 4.9
VT-2TCM HAB CBL 0.97 8.1 0.87 3.4 2.9
VT-2TCM MAB CBL 0.99 6.6 0.17 5.9 6
VT-2TCM All WB 1 3.6 0.52 3 2.5
VT-2TCM HAB WB 1.1 3 0.33 3.1 2.4
VT-2TCM MAB WB 1 3.7 0.55 2.9 2.5
SUV4060 min HAB 1.1 22 0.76 13 11
SUV4060 min MAB 0.8 31 0.91 13 9.1
SUV4060 min All CBL 0.95 6.2 0.63 4.4 3.8
SUV4060 min HAB CBL 0.94 7.5 0.85 3.2 2.9
SUV4060 min MAB CBL 0.95 5.2 0.32 5.4 4.3
SUV4060 min All WB 1 3.9 0.89 1.5 1.3
SUV4060 min HAB WB 1 1.9 0.6 1.3 1.2
SUV4060 min MAB WB 1 4 0.89 1.6 1.3
  1. HAB high-affinity binders, MAB mixed-affinity binders, CBL cerebellum, WB whole brain, COV coefficient of variance (%), ICC intraclass correlation coefficient, VAR absolute percentage variability (%), SEM standard error of measurement (%)