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EJNMMI Research

Table 2 Mean absorbed doses to normal organs and tumor for 225Ac-DOTA-anti-PD-L1-BC (15 kBq, 3 mg/kg)

From: Pharmacokinetics, microscale distribution, and dosimetry of alpha-emitter-labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer model

Organ

Mean absorbed dose (mGy/kBq)

Blood

80.4

Heart

42.5

Lungs

53.0

Liver

738

Spleen

615

Kidneysa

138

Stomach

30.2

Intestine

42.8

Bone

69.7

Thymus

282

Muscle

11.8

BAT

57.5

Tumor

141

  1. aIncludes contribution from free 213Bi and 225Ac-DOTA-anti-PD-L1-BC
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