Fig. 5
From: Monitoring response to anti-angiogenic mTOR inhibitor therapy in vivo using 111In-bevacizumab
The effect of rapamycin on FaDu xenografts. a Changes in tumour volume with rapamycin therapy. On day 10, tumour volumes are significantly different (P = 0.0004). b Select images of CD31 confocal microscopy of tumours from mice treated with rapamycin. c Changes in relative mean vessel size with rapamycin therapy. d Changes of relative mean vessel density of rapamycin. e Uptake changes of 111In-bevacizumab and 111In-IgGκ in FaDu xenografts treated with rapamycin (20 mg/kg). The control groups were treated with vehicle injections. Data are presented as mean ± SEM, **P < 0.01, ***P < 0.001, ****P < 0.0001, n = 6–7/group