Table 1 Intra- and inter-reader coefficients of variation using VOI/ROIs [median (range)]

 Overall group

3.69% (1.90–7.05%)

4.20% (1.74–8.30%)

1.52% (0.48–3.78%)

p < 0.001

 Reader #1

4.03% (1.90–7.05%)

4.83% (2.58–8.30%)

1.04% (0.55–3.00%)

p < 0.001

 Reader #2

5.16% (2.37–6.23%)

4.38% (2.79–5.98%)

1.49% (0.97–2.25%)

p < 0.001

 Reader #3

2.86% (2.07–5.38%)

2.72% (1.74–3.53%)

1.19% (0.48–2.27%)

p < 0.001

 Reader #4

2.99% (2.23–4.20%)

3.97% (2.59–6.68%)

2.06% (1.11–2.75%)

p < 0.001

 Reader #5

2.62% (1.95–4.06%)

3.09% (2.02–5.04%)

1.05% (0.39–2.42%)

p < 0.001

 Reader #6

4.74% (2.42–6.96%)

5.46% (3.04–6.57%)

1.97% (1.07–3.78%)

p < 0.001

 Overall group

3.83% (1.80–7.46%)

4.02% (1.47–6.32%)

2.14% (1.05–7.23%)

p = 0.001