Fig. 4

The dose–response for all lesions follows the expected relationship when measuring response with change in TLG (R = 0.61, when fitted with a function of the form: \( y=100- a{e}^{- bx} \)) (a); this relationship is not demonstrated when change in SUV_peak is used to measure response (R = 0.33) (b). Using D₇₀ instead of D_avg as the metric slightly improves the correlation further (R = 0.63) (c). A 50 Gy cut-off (dashed line) corresponds to a significant response in all but two lesions (a)