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Table 2 Parameter values across HV (N = 10) and COPD (N = 10) subjects in four lung ROIs

From: Quantitative analysis of dynamic 18F-FDG PET/CT for measurement of lung inflammation

   Whole lung Upper lung Middle lung Lower lung
   HV COPD HV COPD HV COPD HV COPD
V A CT μ 0.72 0.79 0.74 0.80 0.72 0.79 0.68 0.78
CoV (%) 6.0 5.2 5.0 7.3 6.0 5.1 7.7 4.4
SUV μ 0.63 0.45 0.60 0.45 0.62 0.45 0.68 0.45
CoV (%) 20 26 18 37 21 25 20 25
Patslope μ (×10−3) 0.61 0.51 0.54 0.52 0.57 0.51 0.73 0.50
CoV (%) 21 22 30 35 26 22 31 33
Patintcpt μ 0.21 0.13 0.21 0.13 0.21 0.13 0.23 0.13
CoV (%) 13 26 12 38 14 24 17 26
nK i Pat μ (×10−3) 2.9 3.9 2.7 4.1 2.72 3.9 3.4 3.8
CoV (%) 19 18 31 28 23 18 42 31
K i μ (×10−3) 6.0 5.7 7.2 6.3 5.9 6.2 5.4 4.8
CoV (%) 32 29 42 37 32 35 46 40
V B μ 0.14 0.11 0.15 0.12 0.15 0.12 0.11 0.10
CoV (%) 18 36 18 49 18 37 27 26
  1. \( {V}_A^{CT} \) fractional air volume measured using CT-AC, SUV standardised uptake value, Pat slope Patlak slope, Pat intcpt Patlak intercept, \( n{K}_i^{Pat} \) ratio Patslope/Patintcpt, K i air and blood corrected metabolic rate of 18F-FDG in lung tissue, V B fractional blood volume