Quantitative analysis of dynamic 18F-FDG PET/CT for measurement of lung inflammation

EJNMMI Research

Table 2 Parameter values across HV (N = 10) and COPD (N = 10) subjects in four lung ROIs

		Whole lung		Upper lung		Middle lung		Lower lung
		HV	COPD	HV	COPD	HV	COPD	HV	COPD
V _A ^CT	μ	0.72	0.79	0.74	0.80	0.72	0.79	0.68	0.78
V _A ^CT	CoV (%)	6.0	5.2	5.0	7.3	6.0	5.1	7.7	4.4
SUV	μ	0.63	0.45	0.60	0.45	0.62	0.45	0.68	0.45
SUV	CoV (%)	20	26	18	37	21	25	20	25
Pat^slope	μ (×10⁻³)	0.61	0.51	0.54	0.52	0.57	0.51	0.73	0.50
Pat^slope	CoV (%)	21	22	30	35	26	22	31	33
Pat^intcpt	μ	0.21	0.13	0.21	0.13	0.21	0.13	0.23	0.13
Pat^intcpt	CoV (%)	13	26	12	38	14	24	17	26
nK _i ^Pat	μ (×10⁻³)	2.9	3.9	2.7	4.1	2.72	3.9	3.4	3.8
nK _i ^Pat	CoV (%)	19	18	31	28	23	18	42	31
K _i	μ (×10⁻³)	6.0	5.7	7.2	6.3	5.9	6.2	5.4	4.8
K _i	CoV (%)	32	29	42	37	32	35	46	40
V _B	μ	0.14	0.11	0.15	0.12	0.15	0.12	0.11	0.10
V _B	CoV (%)	18	36	18	49	18	37	27	26

\( {V}_A^{CT} \) fractional air volume measured using CT-AC, SUV standardised uptake value, Pat ^slope Patlak slope, Pat ^intcpt Patlak intercept, \( n{K}_i^{Pat} \) ratio Pat^slope/Pat^intcpt, K _i air and blood corrected metabolic rate of ¹⁸F-FDG in lung tissue, V _B fractional blood volume