Table 2 Residence times, organ absorbed doses and EDs according ICRP60 and ICRP103 for 30-min and 1-h urinary voiding cycles in men. Extrapolated organ dose in female and defence person is reported for 1-h urinary voiding cycle only
From: First in-human radiation dosimetry of 68Ga-NODAGA-RGDyK
Patient cohort (n = 5 male) | Female | Reference | ||||||
|---|---|---|---|---|---|---|---|---|
Residence time | 0.5-h voiding | 1-h voiding | 1-h voiding | |||||
Target organ | Mean (hours) | SD | Dose (mGy/MBq) | SD | Dose (mGy/MBq) | SD | Dose (mGy/MBq) | Dose (mGy/MBq) |
Adrenals | 6.40E−03 | 5.42E−04 | 6.42E−03 | 5.37E−04 | 8.18E−03 | 7.30E−03 | ||
Brain | 3.20E−03 | 7.09E−04 | 1.77E−03 | 2.64E−04 | 1.77E−03 | 2.64E−04 | 2.15E−03 | 1.96E−03 |
Breasts | 4.58E−03 | 2.99E−04 | 4.58E−03 | 2.96E−04 | 5.86E−03 | 5.22E−03 | ||
Gallbladder wall | 7.01E−03 | 6.41E−04 | 7.07E−03 | 6.44E−04 | 8.69E−03 | 7.88E−03 | ||
LLI walla | 8.87E−03 | 2.38E−03 | 2.05E−02 | 4.03E−03 | 2.12E−02 | 4.04E−03 | 2.41E−02 | 2.27E−02 |
Small intestinea | 4.52E−02 | 1.14E−02 | 3.01E−02 | 6.43E−03 | 3.03E−02 | 6.45E−03 | 3.54E−02 | 3.29E−02 |
Stomach walla | 6.16E−03 | 2.06E−03 | 1.13E−02 | 1.95E−03 | 1.13E−02 | 1.97E−03 | 1.36E−02 | 1.25E−02 |
ULI walla | 1.16E−02 | 3.35E−03 | 1.85E−02 | 3.78E−03 | 1.87E−02 | 3.77E−03 | 2.18E−02 | 2.03E−02 |
Heart walla | 1.41E−02 | 3.12E−03 | 1.29E−02 | 1.83E−03 | 1.29E−02 | 1.83E−03 | 1.53E−02 | 1.41E−02 |
Kidneys | 2.86E−02 | 7.27E−03 | 4.63E−02 | 1.14E−02 | 4.64E−02 | 1.13E−02 | 5.06E−02 | 4.85E−02 |
Liver | 5.11E−02 | 1.31E−02 | 1.55E−02 | 3.64E−03 | 1.56E−02 | 3.61E−03 | 2.08E−02 | 1.82E−02 |
Lungs | 3.01E−02 | 3.92E−03 | 1.55E−02 | 1.90E−03 | 1.55E−02 | 1.90E−03 | 1.93E−02 | 1.74E−02 |
Muscle | 5.28E−03 | 3.72E−04 | 5.45E−03 | 3.87E−04 | 6.88E−03 | 6.17E−03 | ||
Ovaries | N/A | N/A | N/A | N/A | 1.04E−02 | 9.28E−03 | ||
Pancreas | 1.43E−03 | 7.16E−04 | 1.01E−02 | 3.70E−03 | 1.01E−02 | 3.68E−03 | 1.16E−02 | 1.09E−02 |
Red marrow | 1.44E−02 | 2.81E−03 | 7.12E−03 | 3.84E−04 | 7.23E−03 | 3.79E−04 | 7.98E−03 | 7.61E−03 |
Osteogenic cells | 8.57E−03 | 4.09E−04 | 8.64E−03 | 4.10E−04 | 1.17E−02 | 1.02E−02 | ||
Skin | 4.36E−03 | 2.95E−04 | 4.43E−03 | 2.98E−04 | 5.60E−03 | 5.02E−03 | ||
Spleen | 1.08E−02 | 7.26E−03 | 2.98E−02 | 1.85E−02 | 2.98E−02 | 1.85E−02 | 3.60E−02 | 3.28E−02 |
Testes | 5.34E−03 | 3.77E−04 | 5.81E−03 | 4.43E−04 | N/A | 2.91E−03 | ||
Thymus | 5.24E−03 | 3.33E−04 | 5.24E−03 | 3.33E−04 | 6.68E−03 | 5.96E−03 | ||
Thyroid | 3.99E−04 | 2.10E−04 | 9.81E−03 | 4.29E−03 | 9.81E−03 | 4.29E−03 | 1.17E−02 | 1.08E−02 |
Urinary bladder walla | 7.32E−02 | 1.51E−02 | 8.94E−02 | 1.73E−02 | 1.51E−01 | 2.99E−02 | 2.03E−01 | 1.77E−01 |
Uterus | N/A | N/A | N/A | N/A | 1.20E−02 | 1.09E−02 | ||
Total body | 8.77E−01 | 6.75E−02 | 6.49E−03 | 5.24E−04 | 6.68E−03 | 5.32E−04 | 8.46E−03 | 7.57E−03 |
ED ICRP60 | 1.57E−02 | 1.50E−03 | 1.93E−02 | 1.95E−03 | 2.43E−02 | 2.07E−02 | ||
ED ICRP103 | 1.65E−02 | 1.68E−03 | 1.98E−02 | 1.98E−03 | 2.25E−02 | 1.90E−02 | ||