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Table 1 Results after treatment with 213Bi-MX35 and unlabeled MX35

From: Therapeutic efficacy of α-radioimmunotherapy with different activity levels of the 213Bi-labeled monoclonal antibody MX35 in an ovarian cancer model

Group

Treatment

Activity concentration

Macroscopic tumor (no. of animals)

Microscopic tumor (no. of animals)

Ascites (no. of animals)

TFF

1

213Bi-MX35

3 MBq/mL

4/20

9/20

0

0.55

2

213Bi-MX35

9 MBq/mL

1/18a

4/18a

0

0.78

3

Ref. group (cold MX35)

7/20

17/20

4

0.15

  1. TFF tumor-free fraction, i.e., fraction of the mouse groups with no macroscopic or microscopic tumors and no ascites
  2. aTwo animals were excluded from the mouse group receiving 9 MBq/mL; one was sacrificed earlier because of atypical mouse behavior (no tumor tissue could be detected), and one was excluded because of a sole subcutaneous tumor outside of the peritoneum which was suspected to be the result of cell leakage from the peritoneal cavity post inoculation