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Fig. 1 | EJNMMI Research

Fig. 1

From: Tracking dendritic cell migration into lymph nodes by using a novel PET probe 18F-tetrafluoroborate for sodium/iodide symporter

Fig. 1

Schematic representation of the in vivo tracking of DC migration by performing multimodal reporter gene imaging. The multimodal reporter system involves the NIS, Luc2, and Thy1.1 genes, which act as nuclear reporter, optical reporter, and surrogate for the NIS and Luc2 genes, respectively. The multimodal reporter genes were introduced into DCs retrovirally, and the reporter-tagged DCs were injected into the muscles and footpads of mice. Next, combined PET/CT imaging (18F-TFB) and BLI (d-luciferin) was performed

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