Skip to main content

Table 5 HPLC monitoring of the n.i RCY of [18F]EFB

From: Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7

Entry Temp (°C) [18F]EFB RCY (% ± SEM) Unreacted compound 3 RCY (% ± SEM) Major by-product RCY (% ± SEM)
1 120 41.4 ± 8.2 (n = 2) 7.0 ± 0.8 (n = 2) 13.7 ± 4.5 (n = 2)
2 125 39.0 ± 7.9 (n = 2) 15.3 ± 10.6 (n = 2) 19.6 ± 14.9 (n = 2)
3 130 43.5 ± 8.9 (n = 2) 10.1 ± 2.2 (n = 2) 41.4 ± 8.2 (n = 2)
4 140 35.9 ± 2.4 (n = 2) 6.2 ± 2.2 (n = 2) 47.6 ± 3.3 (n = 2)
5 150 41.1 ± 2.3 (n = 3) 4.5 ± 1.9 (n = 3) 38.5 ± 2.5 (n = 3)
6 160 43.8 ± 0.8 (n = 2) 3.5 ± 1.8 (n = 2) 38.6 ± 2.9 (n = 2)