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EJNMMI Research

Table 5 HPLC monitoring of the n.i RCY of [18F]EFB

From: Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7

Entry

Temp (°C)

[18F]EFB RCY (% ± SEM)

Unreacted compound 3 RCY (% ± SEM)

Major by-product RCY (% ± SEM)

1

120

41.4 ± 8.2 (n = 2)

7.0 ± 0.8 (n = 2)

13.7 ± 4.5 (n = 2)

2

125

39.0 ± 7.9 (n = 2)

15.3 ± 10.6 (n = 2)

19.6 ± 14.9 (n = 2)

3

130

43.5 ± 8.9 (n = 2)

10.1 ± 2.2 (n = 2)

41.4 ± 8.2 (n = 2)

4

140

35.9 ± 2.4 (n = 2)

6.2 ± 2.2 (n = 2)

47.6 ± 3.3 (n = 2)

5

150

41.1 ± 2.3 (n = 3)

4.5 ± 1.9 (n = 3)

38.5 ± 2.5 (n = 3)

6

160

43.8 ± 0.8 (n = 2)

3.5 ± 1.8 (n = 2)

38.6 ± 2.9 (n = 2)

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