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EJNMMI Research

Table 3 Comparison of regional gray matter V T of four TSPO ligands measured in human subjects

From: Assessment of safety, efficacy, and dosimetry of a novel 18-kDa translocator protein ligand, [11C]CB184, in healthy human volunteers

Ligand

Frontal cortex

Temporal cortex

Parietal cortex

Occipital cortex

Putamen

Caudate

Thalamus

Cerebellum

[11C]CB184

4.0 ± 0.2

3.9 ± 0.4

3.9 ± 0.3

4.3 ± 0.5

4.0 ± 0.2

3.2 ± 0.1

5.1 ± 0.4

4.4 ± 0.2

[11C]DPA-713 [15]

4.1 ± 0.8

–

3.7 ± 0.7

–

3.5 ± 0.6

3.1 ± 0.6

4.7 ± 0.9

3.9 ± 0.9

(R)-[11C]PK11195 [15]

0.3 ± 0.1

–

0.4 ± 0.1

–

0.3 ± 0.1

0.3 ± 0.1

0.4 ± 0.1

0.3 ± 0.1

[11C]PBR28 [13]

–

–

3.9 ± 1.1

–

–

3.3 ± 1.0

4.6 ± 1.6

4.1 ± 1.3

  1. Data represent the mean ± SD for healthy typical male subjects (n = 4). Data for [11C]DPA-713, (R)-[11C]PK11195, and [11C]PBR28 were taken from previously published reports [13, 15]
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