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Table 3 Comparison of regional gray matter V T of four TSPO ligands measured in human subjects

From: Assessment of safety, efficacy, and dosimetry of a novel 18-kDa translocator protein ligand, [11C]CB184, in healthy human volunteers

Ligand Frontal cortex Temporal cortex Parietal cortex Occipital cortex Putamen Caudate Thalamus Cerebellum
[11C]CB184 4.0 ± 0.2 3.9 ± 0.4 3.9 ± 0.3 4.3 ± 0.5 4.0 ± 0.2 3.2 ± 0.1 5.1 ± 0.4 4.4 ± 0.2
[11C]DPA-713 [15] 4.1 ± 0.8 3.7 ± 0.7 3.5 ± 0.6 3.1 ± 0.6 4.7 ± 0.9 3.9 ± 0.9
(R)-[11C]PK11195 [15] 0.3 ± 0.1 0.4 ± 0.1 0.3 ± 0.1 0.3 ± 0.1 0.4 ± 0.1 0.3 ± 0.1
[11C]PBR28 [13] 3.9 ± 1.1 3.3 ± 1.0 4.6 ± 1.6 4.1 ± 1.3
  1. Data represent the mean ± SD for healthy typical male subjects (n = 4). Data for [11C]DPA-713, (R)-[11C]PK11195, and [11C]PBR28 were taken from previously published reports [13, 15]