Voxel-based mapping of grey matter volume and glucose metabolism profiles in amyotrophic lateral sclerosis

EJNMMI Research

Table 2 Labellization. MNI coordinates. Cluster size in number of voxels (K) and T value of the significant peaks for the SPM analyze of GM atrophy, hypometabolism, hypermetabolism and GM atrophy > hypometabolism and hypometabolism > GM atrophy

Labels	K	MNI coordinates			p corrected at the cluster level	p FWE corrected at voxel level	T (voxel level)
Labels		x	y	z
GM atrophy
L postcentral	569	−53	−12	29	0.518	0.036	5.18
L inferior temporal gyrus	3146	−27	9	−33	0.002	0.102	4.86
L paracentral lobule	1331	−4	−27	64	0.084	0.133	4.77
L supramarginal gyrus	484	−52	−22	31	0.621	0.159	4.71
R precentral gyrus	1115	16	−26	67	0.14	0.541	4.23
R putamen	771	35	0	4	0.323	0.785	3.99
Hypometabolism
R paracentral lobule	218	4	−22	70	0.217	0.032	5.21
L inferior parietal gyrus	142	−50	−24	34	0.398	0.099	4.26
R thalamus	244	8	−16	4	0.176	0.31	3.92
L superior medial frontal gyrus	142	−8	40	36	0.398	0.314	3.91
L thalamus	144	−8	−18	6	0.392	0.564	3.87
Hypermetabolism
L hippocampus	868	−22	−18	−18	0.003	0.008	5.33
L parahippocampus
L fusiform
Vermis VII	941	−2	−72	−32	0.002	0.044	4.82
Vermis IV–V
R fusiform	557	22	−32	−20	0.019	0.163	4.39
R cerebellum IV–V
R parahippocampal gyrus
R hippocampus
Atrophy > hypometabolism
L parahippocampus	147	−26	4	−30	0	0.709	4.85
L middle temporal pole
L calcarine	36	−4	−96	8	0.109	0.784	4.76
R middle temporal pole	58	46	12	−26	0.013	0.936	4.52
L inferior temporal gyrus	87	−50	−6	−32	0.001	0.997	4.2
L hippocampus	56	−30	−12	−22	0.016	1	4.05
Hypometabolism > atrophy
L superior medial frontal gyrus	48	−6	34	40	0.033	1	4.06