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Table 3 Regional distribution volume (VT) estimates from the three different methods for each of the groups. Data are expressed as mean ± SD for the tracer dose group (n = 10) and as individual values for the pre-saturated group (n = 2)

From: Pharmacokinetic modeling of [11C]flumazenil kinetics in the rat brain

   VT  
Region 2TCM 1TCM SA
Tracer dose (n = 10)    
Frontal cortex 7.81 ± 1.10 7.80 ± 2.38 7.15 ± 1.17
Hippocampus 6.86 ± 0.94 6.84 ± 2.08 6.55 ± 0.95
Cerebellum* 4.44 ± 0.67 4.11 ± 1.24 4.33 ± 0.65
Medulla* 2.77 ± 0.48 2.35 ± 0.71 2.66 ± 0.39
Pons* 2.54 ± 0.40 2.10 ± 0.61 2.45 ± 0.33
Pre-saturated (n = 2)    
Frontal cortex 1.23 and 1.10 0.67 and 0.73 1.00 and 0.89
Hippocampus 1.07 and 0.92 0.60 and 0.62 1.09 and 0.68
Cerebellum 0.98 and 0.91 0.52 and 0.58 1.00 and 0.69
Medulla 0.89 and 0.80 0.46 and 0.56 0.69 and 0.83
Pons 0.99 and 0.88 0.55 and 0.59 0.80 and 0.72
  1. *Significant differences were found in these regions between 1TCM and 2TCM estimates (p < 0.005) as well as between 1TCM and SA (p < 0.05)