From: Pharmacokinetic modeling of [11C]flumazenil kinetics in the rat brain
Micro parameters | Macro parameters | ||
---|---|---|---|
k3 | VT | DVR–1 | BPND |
(min−1) | (K1/k2) × [1 + (k3/k4) + (k5/k6)] | (k3/k4) | |
0.20 | 1.44 | 0 | 1.17 |
0.35 | 1.75 | 0.22 | 2.05 |
0.50 | 2.06 | 0.43 | 2.94 |
0.65 | 2.38 | 0.65 | 3.82 |
0.80 | 2.69 | 0.87 | 4.70 |
0.95 | 3.00 | 1.09 | 5.58 |
1.10 | 3.32 | 1.30 | 6.47 |
1.25 | 3.63 | 1.52 | 7.35 |
1.40 | 3.95 | 1.74 | 8.23 |
1.55 | 4.26 | 1.96 | 9.11 |
1.70 | 4.58 | 2.18 | 10.0 |
1.85 | 4.89 | 2.39 | 10.8 |
2.00 | 5.20 | 2.61 | 11.7 |
2.15 | 5.51 | 2.83 | 12.6 |
2.30 | 5.83 | 3.05 | 13.5 |
2.45 | 6.14 | 3.27 | 14.4 |
2.60 | 6.46 | 3.48 | 15.3 |