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Table 2 Overview of the micro and macro parameters used for the simulated TACs

From: Pharmacokinetic modeling of [11C]flumazenil kinetics in the rat brain

Micro parameters Macro parameters
k3 VT DVR–1 BPND
(min−1) (K1/k2) × [1 + (k3/k4) + (k5/k6)]   (k3/k4)
0.20 1.44 0 1.17
0.35 1.75 0.22 2.05
0.50 2.06 0.43 2.94
0.65 2.38 0.65 3.82
0.80 2.69 0.87 4.70
0.95 3.00 1.09 5.58
1.10 3.32 1.30 6.47
1.25 3.63 1.52 7.35
1.40 3.95 1.74 8.23
1.55 4.26 1.96 9.11
1.70 4.58 2.18 10.0
1.85 4.89 2.39 10.8
2.00 5.20 2.61 11.7
2.15 5.51 2.83 12.6
2.30 5.83 3.05 13.5
2.45 6.14 3.27 14.4
2.60 6.46 3.48 15.3
  1. Fixed micro parameters (min−1) K1 = 0.8; k2 = 2.25; k4 = 0.17; k5 = 0.15; k6 = 0.08