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Table 2 Overview of the micro and macro parameters used for the simulated TACs

From: Pharmacokinetic modeling of [11C]flumazenil kinetics in the rat brain

Micro parameters

Macro parameters

k3

VT

DVR–1

BPND

(min−1)

(K1/k2) × [1 + (k3/k4) + (k5/k6)]

 

(k3/k4)

0.20

1.44

0

1.17

0.35

1.75

0.22

2.05

0.50

2.06

0.43

2.94

0.65

2.38

0.65

3.82

0.80

2.69

0.87

4.70

0.95

3.00

1.09

5.58

1.10

3.32

1.30

6.47

1.25

3.63

1.52

7.35

1.40

3.95

1.74

8.23

1.55

4.26

1.96

9.11

1.70

4.58

2.18

10.0

1.85

4.89

2.39

10.8

2.00

5.20

2.61

11.7

2.15

5.51

2.83

12.6

2.30

5.83

3.05

13.5

2.45

6.14

3.27

14.4

2.60

6.46

3.48

15.3

  1. Fixed micro parameters (min−1) K1 = 0.8; k2 = 2.25; k4 = 0.17; k5 = 0.15; k6 = 0.08