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Table 2 Results for Monte Carlo-simulated SPECT images at 336 h p.i. in terms of volume error, DSC and activity-concentration error

From: SPECT image segmentation for estimation of tumour volume and activity concentration in 177Lu-DOTATATE radionuclide therapy

Method Volume/cm3 Volume error (%) DSC Activity concentration error (%)
   ASR AS ASR AS ASR/ASR AS/ASR AS/AS
OM 2.75 −23±15 (27) 119±43 (126) 0.73 (0.65, 0.76) 0.44 (0.40, 0.50) 24±21 (31) −52±10 (53) −5±22 (22)
  3.39 −38±11 (39) 54±23 (59) 0.69 (0.59, 0.74) 0.56 (0.49, 0.60) 36±19 (41) −36±8 (36) 9±14 (16)
  5.30 −33±7 (34) 37±17 (40) 0.72 (0.70, 0.76) 0.57 (0.53, 0.61) 25±10 (27) −35±5 (35) 4±11 (11)
  8.89 −38±10 (39) −6±9 (10) 0.73 (0.64, 0.77) 0.52 (0.48, 0.57) 27±15 (31) −29±6 (30) 39±10 (40)
  19.2 −27±5 (27) −12±5 (13) 0.81 (0.78, 0.84) 0.67 (0.65, 0.70) 21±7 (22) −10±5 (11) 30±6 (31)
  40.0 −20±2 (20) −29±6 (30) 0.86 (0.84, 0.87) 0.68 (0.66, 0.72) 15±2 (15) −1±3 (3) 38±7 (39)
  43.1 −20±2 (20) −24±4 (24) 0.87 (0.86, 0.88) 0.74 (0.72, 0.77) 13±2 (13) 1±2 (3) 32±4 (32)
  45.5 −26±2 (26) −17±3 (17) 0.83 (0.81, 0.84) 0.71 (0.69, 0.73) 18±2 (18) −8±2 (8) 16±4 (17)
FS 2.75 −20±6 (21) 35±25 (43) 0.74 (0.71, 0.76) 0.73 (0.68, 0.76) 16±10 (19) −16±13 (21) 8±19 (20)
  3.39 −31±7 (32) 25±26 (36) 0.69 (0.65, 0.74) 0.72 (0.67, 0.75) 24±10 (26) −14±13 (19) 8±16 (18)
  5.30 −25±6 (25) 33±17 (37) 0.74 (0.72, 0.76) 0.73 (0.70, 0.75) 14±6 (15) −21±7 (22) −10±8 (13)
  8.89 −50±9 (50) 2±14 (14) 0.65 (0.57, 0.73) 0.77 (0.71, 0.81) 39±16 (42) −10±9 (13) 1±11 (11)
  19.2 −39±6 (40) −13±9 (16) 0.74 (0.68, 0.80) 0.84 (0.80, 0.86) 31±8 (32) 7±7 (10) 15±8 (17)
  40.0 −21±2 (21) −8±7 (11) 0.86 (0.84, 0.87) 0.88 (0.82, 0.89) 14±2 (14) 4±5 (6) 3±5 (6)
  43.1 −23±2 (23) −9±4 (10) 0.86 (0.84, 0.87) 0.89 (0.88, 0.90) 14±2 (14) 4±3 (5) 9±3 (9)
  45.5 −34±2 (34) −9±7 (11) 0.78 (0.76, 0.81) 0.86 (0.84, 0.87) 24±3 (24) 2±5 (5) −3±4 (5)
  1. Results for volume and activity concentration are given as \(\bar {E_{j}}\pm \text {rSD}_{j}\,\left (\text {rRMSE}_{j}\right)\). For the DSC the 50th (10th, 90th) percentiles are given. Results are given for image segmentation on SPECT images reconstructed with AS and ASR. For activity concentration, results are presented for combinations of ASR and AS, for example AS/ASR where the first (AS) specifies the SPECT image used for tumour delineation while the second (ASR) refers to the SPECT images on which the resulting VOIs were applied. Results of FT have been omitted due to its poor performance causing the results not being deemed meaningful