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Fig. 1 | EJNMMI Research

Fig. 1

From: The extent to which standardized uptake values reflect FDG phosphorylation in the liver and spleen as functions of time after injection of 18F-fluorodeoxyglucose

Fig. 1

Model of intrahepatic FDG kinetics. K 1 is hepatic blood flow, k 2 is a diffusion constant, k 3 the glucokinase and k4 glucose-6-phosphatase. FDG is assumed to mix throughout its intrahepatic distribution volume via K 1 and k 2 by 2–3 min post-injection. De-phosphorylation (via k 4) is assumed to be slow enough to ignore in Patlak-Rutland analysis, which therefore measures phosphorylation rate. The corresponding model for the spleen is similar except k 4 is lacking

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